Galactopyranoside Derivatives as Potential Antibacterial Therapeutic Drugs for Pharmaceutical Uses | Chapter 8 | Novel Aspects on Chemistry and Biochemistry Vol. 6

Carbohydrate products are an important part of biochemical and healing studies, so it is important to understand their allure and biochemistry. Carbohydrates, the most handy organic biomolecules, remain an appealing research subject for scientists on account of their vital role in organic systems. Previously, a group of methyl-D-galactopyranoside (MGP, 1) descendants were synthesized, and their structures were distinguished. In vitro biological tests against five microorganisms and two fungi, as well as the forecast of activity spectra for elements (PASS), revealed that the antifungal and uncontaminated activities were greater than their antiviral exercises. On the basis of their uncontaminated properties, minimum inhibitory concentration (MIC) and minimum completely clean concentration (MBC) experiments were administered on derivatives 3 and 9 to decide their MIC and MBC. The mycelial growth of fungi was inhibited by >780% by most of these compounds. The synthetic descriptors and thermodynamic properties were determined using density working theory (DFT). Additionally, microscopic docking was conducted against decontaminating drug targets, expressly PDB: 4QDI, 5A5E, 7D27, 1ZJI, 3K8E, and 2MRW, as well as antifungal drug targets, that is to say, PDB: 1EA1 and 1AI9. The objective was to label potential drug candidates for microbial pathogens. Stable shape and binding patterns were observed in a fascinating atmosphere using a microscopic dynamics simulation accompanying a duration of 100 ns. All of the settled -MGP derivatives exhibited potential in silico pharmacokinetic studies due to their improved kinetic characteristics and discounted aquatic and nonaquatic toxicities. The recently synthesized MGP products were shown to be hopeful antibacterial/antifungal nominees based on the results of biological, makeup-activity connection (SAR) [lauroyl-(CH3(CH2)10CO- group was found to have potential] and in silico computational analyses and can be a part of therapeutic drug marks for pharmaceutical uses.

Author(s) Details:

Sarkar M. A. Kawsar,
Department of Chemistry, Laboratory of Carbohydrate and Nucleoside Chemistry (LCNC), Faculty of Science, University of Chittagong, Chittagong-4331, Bangladesh.

Please see the link here: https://stm.bookpi.org/NACB-V6/article/view/11720