Innovative Diagnostic Method Using Immunocytochemistry (Estrogen Receptor) for Diagnosis and Management of Breast Cancer | Chapter 15 | Current Progress in Medicine and Medical Research Vol. 9

This study proposed to evaluate the influence of Immunocytochemistry (ICC) on Fine Needle Aspiration Cytology (FNAC) using estrogen receptor (ER), in diagnosing conscience lesions, equating them to success standard Core Needle Biopsy with Immunohistochemistry (IHC). A total of 50 samples were composed and analyzed utilizing both FNAC and Core Needle Biopsy methods.For FNAC, the results demonstrated superior depiction: Sensitivity=100%, Specificity=100%, Diagnostic Accuracy=100%, Positive Predictive Value (PPV)=100%, and Negative Predictive Value (NPV)=100%.Similarly, the results for ICC using ER were too favorable: Sensitivity=100%, Accuracy=100%, Positive Predictive Value= 100% and Negative Predictive Value=100%.These verdicts suggest that ICC utilizing ER could be a part of a trustworthy alternative to the gold-standard demonstrative tests. This technique substantiates particularly valuable in positions where capability disadvantages prevent the use of the standard test. However, it is necessary to note that further studies with a best sample size are essential to generalize these results.Furthermore, this study complicated the utilization of theme dossier analysis on FNAC reports. The study revealed that nearly 11.35% of the dataset contained beneficial words, signifying that normalization processes can abridge the data and manage valuable for assisting dispassionate chart reviews and clinical resolution support systems.

Author(s) Details:

Rohith R. Nair,
J.S.S. Medical College, Mysore, Karnataka- 570015, India.

Sonali Nandish,
Department of Computer Science and Engineering, JSS Science and Technology University, Mysore, Karnataka - 570006, India.

R. J. Prathibha,
Department of Information Science and Engineering, JSS Science and Technology University, Mysore, Karnataka - 570006, India.

N. M. Nandini,
Department of Pathology, JSS Medical College and Hospital, Constituent of JSSAHER, Mysore, Karnataka - 570004, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V9/article/view/11699