Fine Needle Aspiration Cytology for Early Detection of Cutaneous Metastases: Insights from a Tertiary Care Center | Chapter 13 | Medicine and Medical Research: New Perspectives Vol. 7

 

Introduction: Skin metastasis can be the presenting symptom of many malignant tumors. These signs occur a long time before the diagnosis of the primary tumors or their recurrence and sometimes after surgery. These initial cutaneous tumors may aid in the diagnosis of primary tumors.

 

Aim: This study was conducted to identify them and to establish the utility of Fine Needle Aspiration Cytology (FNAC) to diagnose these lesions. As FNAC is a simple, rapid, cost-effective, minimally invasive OPD procedure. No anesthesia or special equipment is needed and it can be practised in a small setup.

 

Materials and Methods: The study was conducted in a tertiary care center. Clinical history, presenting features, and FNAC findings of the cutaneous lesions were noted. Immunocytochemistry(ICC) and Immunohistochemistry (IHC) from cell block were done when necessary. These findings then corroborated with Histopathological diagnosis.

 

Results: This study includes the cases of cutaneous metastatic deposits from various primary visceral malignancies, Lung, Gastrointestinal tract, thyroid, ovary etc. at different sites. The sites of cutaneous metastasis are the chest wall, scalp, and anterior abdominal wall, all over the body. The patients underwent preliminary investigations and FNAC. After a diagnosis of neoplastic lesions, the patients were referred to the Radiology, surgery, and radiotherapy department for further management.

 

Conclusion: Metastatic skin lesions may develop due to lymphatic and blood spread. It may be the first presenting feature of the malignant tumor or its recurrence. This study also proves the efficacy of FNAC in ascertaining the nature of these lesions. The cytological features along with clinical findings and radiological imaging help the early recognition of the primary lesion or identification of recurrence and thus help the clinicians in planning appropriate management.

 

Author (s) Details

 

Madhumita Mukhopadhyay
Department of Pathology, IPGME&R, Kolkata, West Bengal, India and JISMSR, West Bengal, India.

 

Ananya Ghatak
Department of Pathology, IPGME&R, Kolkata, West Bengal, India.

 

Chhanda Das
Department of Pathology, NRSMCH, Kolkata, India.

 

Subhamoy Saha
Department of Pathology, IPGME&R, Kolkata, West Bengal, India.

 

Binata Bandopadhyay
Department of Pathology, Murshidabad Medical College, Berhampore, West Bengal, India.

 

Malabika Baisya
Department of Pathology, IPGME&R, Kolkata, West Bengal, India.

 

Rituparna Kayal
Department of Pathology, IPGME&R, Kolkata, West Bengal, India.

 

Biswanath Mukhopadhyay
Department of Pediatric Surgery, Apollo Multispeciality Hospital, Kolkata, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/mmrnp/v7/2345

Innovative Diagnostic Method Using Immunocytochemistry (Estrogen Receptor) for Diagnosis and Management of Breast Cancer | Chapter 15 | Current Progress in Medicine and Medical Research Vol. 9

This study proposed to evaluate the influence of Immunocytochemistry (ICC) on Fine Needle Aspiration Cytology (FNAC) using estrogen receptor (ER), in diagnosing conscience lesions, equating them to success standard Core Needle Biopsy with Immunohistochemistry (IHC). A total of 50 samples were composed and analyzed utilizing both FNAC and Core Needle Biopsy methods.For FNAC, the results demonstrated superior depiction: Sensitivity=100%, Specificity=100%, Diagnostic Accuracy=100%, Positive Predictive Value (PPV)=100%, and Negative Predictive Value (NPV)=100%.Similarly, the results for ICC using ER were too favorable: Sensitivity=100%, Accuracy=100%, Positive Predictive Value= 100% and Negative Predictive Value=100%.These verdicts suggest that ICC utilizing ER could be a part of a trustworthy alternative to the gold-standard demonstrative tests. This technique substantiates particularly valuable in positions where capability disadvantages prevent the use of the standard test. However, it is necessary to note that further studies with a best sample size are essential to generalize these results.Furthermore, this study complicated the utilization of theme dossier analysis on FNAC reports. The study revealed that nearly 11.35% of the dataset contained beneficial words, signifying that normalization processes can abridge the data and manage valuable for assisting dispassionate chart reviews and clinical resolution support systems.

Author(s) Details:

Rohith R. Nair,
J.S.S. Medical College, Mysore, Karnataka- 570015, India.

Sonali Nandish,
Department of Computer Science and Engineering, JSS Science and Technology University, Mysore, Karnataka - 570006, India.

R. J. Prathibha,
Department of Information Science and Engineering, JSS Science and Technology University, Mysore, Karnataka - 570006, India.

N. M. Nandini,
Department of Pathology, JSS Medical College and Hospital, Constituent of JSSAHER, Mysore, Karnataka - 570004, India.

Please see the link here: https://stm.bookpi.org/CPMMR-V9/article/view/11699