Crush condition (CS) is characterized by ischemia/reperfusion harm (IRI) in skeletal influence caused by direct trauma, harm, and compression. Skeletal muscle demolition following IRI induces massive production of reactive oxygen species and after systemic redness. Recent studies demonstrate that ischemic pre- and post-conditioning weaken IRI by enhancing nitric oxide (NO) synthase incitement and nitrite reduction to NO. The guarding effect of nitrite infusion on experimental IRI again has been demonstrated in courage, kidney, liver, and wasted muscle. Based on the recent progress in healing strategies against CS, we discuss NO-arbitrated signaling connection in CS, and utility of nitrite infusion as a pharmacological attack in the treatment of CS.
Author(s) Details:
Jun Kobayashi,
Division
of Pathophysiology, Department of Clinical Dietetics and Human Nutrition,
Faculty of Pharmacy and Pharmaceutical Science, Josai University, Saitama,
Japan.
Isamu
Murata,
Division
of Drug Safety Management, Faculty of Pharmacy and Pharmaceutical Science,
Josai University, Saitama, Japan.
Please see the link here: https://stm.bookpi.org/CPMMR-V7/article/view/11596
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