Chemical Constituents from Caesalpinia sappan and Their Biological Activity | Chapter 7 | Novel Aspects on Chemistry and Biochemistry Vol. 5

 This study aims to judge the arginase inhibitory activity of unique compounds from Caesalpinia sappan L. heartwood. Based on bioactivity-guided fractionation, the ethyl acetate fraction (prevents arginase activity at a aggregation of 50 μg/mL) was further subjected to column chromatography to get five compounds (1-5). The chemical buildings of the isolated compounds were determined by resolving NMR spectral dossier and referring to data from the biography. The arginase II inhibitory activity of compounds 1-5 was examined in vitro utilizing an enzyme solution processed from the kidney of numb C57BL/6 mice. Compounds 1 and 5 potentially restrict arginase II activity, accompanying IC50 values of 8.1 and 12.6 μM, whereas the staying compounds were inactive. This study is the first to evaluate compounds isolated from C. sappan heartwood with regard to their arginase inhibitory exercise.

Author(s) Details:

Dao-Cuong To,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

Le-Minh Hoang,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

Truong Thi Viet Hoa,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

Truong Thi Thuy Nhung ,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

Hoa-Thi Nguyen,
Phenikaa University Nano Institute (PHENA), Phenikaa University, Yen Nghia, Ha Dong District, Hanoi 12116, Vietnam.

Truong-Nhan Ngu,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Truong Ba Phong,
Department of Natural Sciences and Technology, Tay Nguyen University, 567 Le Duan, Buon Ma Thuot, Dak Lak 630000, Vietnam.

Van-Tinh Nguyen,
Applied Biomedical Research Institute, Buon Ma Thuot Medical University, 298 Ha Huy Tap Str., Buon Ma Thuot, Dak Lak 630000, Vietnam.

Please see the link here: https://stm.bookpi.org/NACB-V5/article/view/11580