This member presents the differential diagnosis of the case of a 23-old age-old female patient refer to the emergency department on account of persistent generalized power weakness, hypokalemia, hypomagnesemia and metabolic alkalosis evenly deteriorating during the last three months in addition to the steps towards final clinical disease of the syndrome (Gitelman disease).The patient’s medical history as well as genealogical chart were thoroughly reviewed by knowledgeable specialized internists. Detailed medical examination was subsequently performed and a committee of blood biochemistry was ordered respectively. Differential diagnosis was acted subsequently.The patient’s medical history was ordinary. Physical examination of the patient did not reveal some abnormal signs. doubly daily blood pressure calculations were within the sane range. Blood tests biochemistry revealed metabolic alkalosis, hypokalemia, hypomagnesemia, hypocalciuria, increased red body fluid renin activity, and elevated body tissue levels of aldosterone. A Gitelman syndrome-like phenotype, containing hypomagnesemia and hypocalciuria, has also been guide mutations in the CLCNKB gene encoding the chloride channel ClC-Kb, the cause of classic Bartter condition. The woman was medicated with spironolactone and oral potassium supplements, and, before her symptoms disappeared and her antitoxin potassium levels returned to common, Gitelman's syndrome was officially investigated. Gitelman syndrome is typically from hypokalemia, metabolic alkalosis, hypomagnesemia, hypocalciuria, increased antitoxin renin and aldosterone levels and normal arterial blood pressure.
Author(s) Details:
Ioannis Karydis,
Department
of Internal Medicine, University of Cyprus, Nicosia, Cyprus.
Dafni
Koumoutsea,
Department
of Endocrinology, Sector of Internal Medicine 401 General Army Hospital of
Athens, Greece and Department of Internal Medicine, NIMTS (Veterans Affairs)
Hospital of Athens, Greece and Division of Renal Medicine, NIMTS (Veterans
Affairs) Hospital of Athens, Greece.
Vasileios German,
Department of Internal Medicine, NIMTS (Veterans Affairs) Hospital
of Athens, Greece.
Ioannis Griveas,
Division of Renal Medicine, NIMTS (Veterans Affairs) Hospital of
Athens, Greece.
Please see the link here: https://stm.bookpi.org/CPMMR-V7/article/view/11669
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