Mannich Bases of Thiosemicarbazide: The Mutual Prodrugs as Anti-Infective Agents | Chapter 4 | Novel Aspects on Pharmaceutical Research Vol. 8

This unit highlights about Mannich Bases of Thiosemicarbazide. The biological exercise of Mannich bases, a structurally heterogeneous class of synthetic compounds that are generated from various substrates through the debut of an aminomethyl function by means of the Mannich backlash, is surveyed, with prominence on the relationship middle from two points structure and biological exercise. The mannich base is an end product in the mannich reaction, that is nucleophilic addition backlash of a non-enolizable aldehyde and any primary or subordinate amine to produce resonance secured imine (iminium ion or imine salt). First variety of mannich bases were combined using aldehyde, ketones and subordinate amines having aliphatic, aromatic, recurrent and heterocyclic nature utilizing mannich reaction. To create mannich bases of thiosemicarbazide as a common prodrug, the synthesized bases were condensed accompanying thiosemicarbazide. Utilizing IR and H-NMR, produced fragments were structurally characterized. Complexity in the reactant's makeup causes changes in reaction opportunity, temperature, and end product yield allotment. Screening of compounds for anti-infectivity was acted in the form of anti- microbial activity utilizing Escherichia Coli (8739) Staphylococcus aureus (25923), anti-fungal activity utilizing Aspergillus niger (16404), Candida albicans (10231) using BHI (intelligence heart infusion) soup dilution form and anti-tubercular action by micro plate Alamar Blue assay (MABA). Structural complexicity plays meaningful role in time necessary, temperature environments and % yield of compounds synthesized.

Author(s) Details:

Sachin A. Pishawikar,
Department of Pharmaceutical Chemistry, New College of Pharmacy, Uchgaon Kolhapur, Maharashtra, India.

Harinath N. More,
Department of Pharmaceutical Chemistry, Bharti Vidyapeeth College of Pharmacy, Near Chitranagari Kolhapur, Maharashtra, India.

Ravindra B. Kumbhar,
Department of Pharmaceutical Chemistry, New College of Pharmacy, Uchgaon Kolhapur, Maharashtra, India.

Sujeet V. Salokhe,
Department of Pharmaceutical Chemistry, New College of Pharmacy, Uchgaon Kolhapur, Maharashtra, India.

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