In vivo Antitumor Activity of Novel 3, 4 di-Substituted Quinazoline Derivatives: A Novel Approach | Chapter 6 | Novel Aspects on Pharmaceutical Research Vol. 7

 This affiliate discussed about in vivo antitumor activity of novel 3, 4 di-substituted quinazoline descendants. Quinazolines were surveyed as biologically appropriate moieties against different cancer container lines. Series of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4 (3H)-one/thione descendants and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were synthesized and characterised by shade resembling such a color (IR), H1 nuclear drawing resonance (NMR) and mass ranges (m/z) and elemental study. In Swiss albino mice presenting Ehrilich ascites carcinoma (EAC), the in-vivo anticancer venture was examined using any of measures, including party weight analysis, mean endurance time, and % increase in life span approaches.  Six compounds (IIh, IIi, IIj, IIIh, IIIi, IIIj)) have proved significant antitumor venture.The research-derived quinazoline derivatives show that the amino group in the tertiary position and the urea/thiourea group in the phenyl hydrazine ring in the tertiary position of the quinzoline skeleton are crucial for anticancer operation.  Compounds IIh, IIi, IIj, IIIh, IIIi and IIIj were found expected biologically active which can be useful as potential means for the discovery of anti-Cancer compound having ordinary quinazoline pharmacophore with lesser poisonous effects.

Author(s) Details:

Biswajit Dash,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal-700126, India.

Biprojit Paul,
Department of Pharmaceutical Chemistry, NETES Institute of Pharmaceutical Sciences, Assam- 781125, India.

T. C. Lalrhiatpuii,
Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram- 786017, India.

Chandana Baishya,
Department of Pharmacology, NEF College of Pharmacy, Sawkuchi, Guwahati-781040, India.

Vikrant V. Chilate,
Taywade Institute of Diploma in Pharmacy, Koradi, Nagpur, Maharashtra-441111, India.

Nayanika Neog,
School of Pharmaceutical Science, University of Science and Technology Meghalaya-793101, India.

Arnab Chakraborty,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal-700126, India.

Kamalesh Mistry,
School of Pharmacy, Rai University, Ahemdabad, Gujrat-382260, India.

Dhunusmita Barman,
NEF College of Pharmaceutical Education and Research, Nagaon, Assam-782001, India.

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