In vivo Antitumor Activity of Novel 3, 4 di-Substituted Quinazoline Derivatives: A Novel Approach | Chapter 6 | Novel Aspects on Pharmaceutical Research Vol. 7

 This affiliate discussed about in vivo antitumor activity of novel 3, 4 di-substituted quinazoline descendants. Quinazolines were surveyed as biologically appropriate moieties against different cancer container lines. Series of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4 (3H)-one/thione descendants and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were synthesized and characterised by shade resembling such a color (IR), H1 nuclear drawing resonance (NMR) and mass ranges (m/z) and elemental study. In Swiss albino mice presenting Ehrilich ascites carcinoma (EAC), the in-vivo anticancer venture was examined using any of measures, including party weight analysis, mean endurance time, and % increase in life span approaches.  Six compounds (IIh, IIi, IIj, IIIh, IIIi, IIIj)) have proved significant antitumor venture.The research-derived quinazoline derivatives show that the amino group in the tertiary position and the urea/thiourea group in the phenyl hydrazine ring in the tertiary position of the quinzoline skeleton are crucial for anticancer operation.  Compounds IIh, IIi, IIj, IIIh, IIIi and IIIj were found expected biologically active which can be useful as potential means for the discovery of anti-Cancer compound having ordinary quinazoline pharmacophore with lesser poisonous effects.

Author(s) Details:

Biswajit Dash,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal-700126, India.

Biprojit Paul,
Department of Pharmaceutical Chemistry, NETES Institute of Pharmaceutical Sciences, Assam- 781125, India.

T. C. Lalrhiatpuii,
Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram- 786017, India.

Chandana Baishya,
Department of Pharmacology, NEF College of Pharmacy, Sawkuchi, Guwahati-781040, India.

Vikrant V. Chilate,
Taywade Institute of Diploma in Pharmacy, Koradi, Nagpur, Maharashtra-441111, India.

Nayanika Neog,
School of Pharmaceutical Science, University of Science and Technology Meghalaya-793101, India.

Arnab Chakraborty,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal-700126, India.

Kamalesh Mistry,
School of Pharmacy, Rai University, Ahemdabad, Gujrat-382260, India.

Dhunusmita Barman,
NEF College of Pharmaceutical Education and Research, Nagaon, Assam-782001, India.

Please see the link here: https://stm.bookpi.org/NAPR-V7/article/view/11436

Pharmacological Evaluation of Novel Quinazoline Derivatives for Their Anti-Convulsant and CNS Depressant Activities | Chapter 2 | Current Overview on Pharmaceutical Science Vol. 7

 The present study tried to design and synthesise isomeric new series of quinazoline-4-one/4-thione descendants, based on the pharmacophoric model of CNS project by structural modifications retaining the essential fundamental features for the exercise and evaluated for their anticonvulsant and CNS depressant features. Epilepsy, a disorder of unprovoked seizures is a versatile disease affecting things of all ages with the predilection for the very young and old. In addition to seizures, many sufferers often report intelligent and psychiatric problems guide both the seizures themselves and its analysis.  A series of 7-chloro-3-[substituted (amino/phenylamino)]-2-phenyl quinazolin-4 (3H)-individual/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were combined. The reaction blueprint proceeds through the intermediate 7-chloro-2-phenyl-4H-benzo[d] [1, 3] oxazin-4-individual. The newly combined compounds were characterized by infrared (IR), 1H basic magnetic reverberation (NMR) and mass spectra (m/z) and basic analysis. The maximum electroshock (MES) taking test and Porsolt's behavioural despair test (forced swimming) were used to analyze the anti-convulsant and CNS depressant venture, respectively. To judge any potential alterations in motor arrangement brought on apiece test compounds, the rota-rod test was transported. The synthesis of quinazoline descendants with a common scaffolding was unequivocally rooted by the physicochemical and spectroscopic data. The synthesised compounds were judged for their anticonvulsant and CNS depressant properties. Six compounds (IIc, IIg, IIj, IIIc, IIIg, IIIj) shown a good activity characterization in CNS depressant activity. Five compounds (IIc, IIg, IIj, IIIg, IIIh) granted protection against MES-persuaded seizures. Compounds IIc, IIg, IIj, IIIc, IIIg, IIIj, and IIIh were found to be a forceful compound which concede possibility be effective as a potential source for the incident of CNS depressant and antagonistic-convulsant drugs with lesser aftereffects.

Author(s) Details:

Biswajit Dash,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Kolkata, West Bengal, 700126, India.

Tochhawng Lalhriatpui,
Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, 786017, India.

Sabnam Parveen,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Kolkata, West Bengal, 700126, India.

Arnab Chakraborty,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Kolkata, West Bengal, 700126, India.

Pdiangmon Kyndait,
The Department of Pharmaceutical Chemistry, School of Pharmacy, The Assam Kaziranga University, Koraikhowa, Jorhat, Assam, 785001, India.

Please see the link here: https://stm.bookpi.org/COPS-V7/article/view/9693

Antimicrobial, Analgesic and Anti-inflammatory Activity of Some Synthesized Quinazoline Derivatives| Chapter 6 | Current Overview on Pharmaceutical Science Vol. 4

 Series of 7-chloro-3-[substituted (amino/phenyl amino)]-2-phenyl quinazolin-4(3H)-individual/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were combined and characterised The reaction proceeds through the middle 7-chloro-2-phenyl-4H-benzo[d] [1, 3] oxazin-4-one. Synthesized compounds were characterised from shade resembling such a color (IR), 1H nuclear magnetic reverberation (NMR) and mass spectra (m/z) and basic analysis. By using the agar spread cup plate method, tail computer-assisted education, and carrageenan-induced paw oedema order, respectively, the uncontaminated, analgesic, and anti-instigative efficacy was examined. Based on the hide data of the new quinazoline derivatives, five compounds are establish to be effective accompanying antimicrobial activity. Five compounds shown good analgesic and anti-angering activity.

Author(s) Details:

Biswajit Dash,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas University, Barasat, Kolkata, West Bengal, 700126, India.

Please see the link here: https://stm.bookpi.org/COPS-V4/article/view/9308