The present study tried to design and synthesise isomeric new series of quinazoline-4-one/4-thione descendants, based on the pharmacophoric model of CNS project by structural modifications retaining the essential fundamental features for the exercise and evaluated for their anticonvulsant and CNS depressant features. Epilepsy, a disorder of unprovoked seizures is a versatile disease affecting things of all ages with the predilection for the very young and old. In addition to seizures, many sufferers often report intelligent and psychiatric problems guide both the seizures themselves and its analysis. A series of 7-chloro-3-[substituted (amino/phenylamino)]-2-phenyl quinazolin-4 (3H)-individual/thione derivatives and 1-(7-chloro-4-oxo/-2-phenylquinazoline-3 (4H-yl)) substituted urea derivatives were combined. The reaction blueprint proceeds through the intermediate 7-chloro-2-phenyl-4H-benzo[d] [1, 3] oxazin-4-individual. The newly combined compounds were characterized by infrared (IR), 1H basic magnetic reverberation (NMR) and mass spectra (m/z) and basic analysis. The maximum electroshock (MES) taking test and Porsolt's behavioural despair test (forced swimming) were used to analyze the anti-convulsant and CNS depressant venture, respectively. To judge any potential alterations in motor arrangement brought on apiece test compounds, the rota-rod test was transported. The synthesis of quinazoline descendants with a common scaffolding was unequivocally rooted by the physicochemical and spectroscopic data. The synthesised compounds were judged for their anticonvulsant and CNS depressant properties. Six compounds (IIc, IIg, IIj, IIIc, IIIg, IIIj) shown a good activity characterization in CNS depressant activity. Five compounds (IIc, IIg, IIj, IIIg, IIIh) granted protection against MES-persuaded seizures. Compounds IIc, IIg, IIj, IIIc, IIIg, IIIj, and IIIh were found to be a forceful compound which concede possibility be effective as a potential source for the incident of CNS depressant and antagonistic-convulsant drugs with lesser aftereffects.
Author(s) Details:
Biswajit Dash,
Department of Pharmaceutical Technology, School
of Medical Sciences, Adamas University, Kolkata, West Bengal, 700126, India.
Tochhawng
Lalhriatpui,
Department
of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl,
Mizoram, 786017, India.
Sabnam Parveen,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas
University, Kolkata, West Bengal, 700126, India.
Arnab Chakraborty,
Department of Pharmaceutical Technology, School of Medical Sciences, Adamas
University, Kolkata, West Bengal, 700126, India.
Pdiangmon
Kyndait,
The Department of Pharmaceutical Chemistry,
School of Pharmacy, The Assam Kaziranga University, Koraikhowa, Jorhat, Assam,
785001, India.
Please see the link here: https://stm.bookpi.org/COPS-V7/article/view/9693
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