Assessment of Iron Burden and Siderosis-related Complications in Patients with Transfusion-dependent Thalassaemia | Chapter 12 | Research Highlights in Disease and Health Research Vol. 8

 Objective: Herein, we aim to determine the iron burden and siderosis-related complications with patients accompanying transfusion-dependent thalassaemia (TDT). We still aim to explore the advantage of cardiac T2* magnetic resonance (MR) to envision potential cardiac complications between patients with TDT.Methods: We acted a cross-sectional study reviewing healing records of 75 TDT patients in Hospital Tuanku Fauziah, Perlis, Malaysia. A total of 151 reports from drawing resonance (MR) T2* performed from 1 January 2015 till 31 December 2021 were reproduced together with appropriate biochemical markers and echocardiogram results that were performed inside the same twelve-month period.Results: We found a moderate correlation 'tween serum ferritin and myocardial (r=0.356, p<0.001), and liver iron loading (r=0.572, p<0.001). There was a moderate equating between antitoxin ferritin and serum ALT (r=0.462, p<0.001), AST (r=0.465, p<0.001), magnesium (p=-0.276, p=0.002) and phosphate (r=-0.221, p=0.014). All patients had sane ejection part, 43 (28.5%) had raised pulmonary artery pressure and nobody had evidence of diastolic dysfunction. There was no predictive changing to predict cardiac complications with our pool of TDT patients.Conclusion: The significant equating between antitoxin ferritin and myocardial/liver iron loading should prompt direct chelation strategy for fear that clinical complications between patients accompanying TDT.

Author(s) Details:

Karniza Khalid,
Specialised Diagnostic Centre, Institute for Medical Research, National Institutes of Health, Kuala Lumpur, Ministry of Health Malaysia, Malaysia.

Nordiyana Azmi,
Department of Paediatrics, Hospital Tuanku Fauziah, Perlis, Ministry of Health Malaysia, Malaysia.

Irma Liyana Mushaddik,
Clinical Research Centre, Hospital Tuanku Fauziah, Perlis, Ministry of Health Malaysia, Malaysia.

Ahmad Afnan Mohamad Puad,
Department of Internal Medicine, Hospital Tuanku Fauziah, Perlis, Ministry of Health Malaysia, Malaysia

Siti Akma Ishak,
Department of Paediatrics, Hospital Tuanku Fauziah, Perlis, Ministry of Health Malaysia, Malaysia.

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