Screening of Antituberculosis Drugs by Thin Layer Chromatography: Experimental Investigation | Chapter 11 | Novel Aspects on Chemistry and Biochemistry Vol. 1

 Tuberculosis resumes to be a main public health issue in underdeveloped countries. In South Asian countries TB is a very universal and prevalent ailment and most of the treatment programmes are controlled directly through administration agencies and emergency rooms. In this study, a novel thin-layer chromatographic screening approach for the labeling of rifampicin, isoniazid, and pyrazinamide in pharmaceutical dosages was manifested. The solvent scheme used to determine these three drugs was (propanol: hexane: ethyl acetate: liquid) (5:2:1.7:0.2 v/v) and the Rf value of rifampicin, pyrazinamide and isoniazid was 0.68, 0.74 and 0.50, individually. The developed arrangement for retention determinant had intra-epoch and inter-era repeatability with a predictable difference (SD) of about 0.5-1.0%.

Author(s) Details:

Abhilasha Durgbanshi,
Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar-470 003, India.

Devasish Bose,
Department of Criminology and Forensic Science, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar-470 003, India.

Please see the link here: https://stm.bookpi.org/NACB-V1/article/view/10440Z