The aim of the study search out reinvestigate the solubility property of NIfedipine as a synthetic for deeper understanding of its pharmacodynamics and efficacy. Nifedipine is chemically dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, a dihydropyridine derivative secondhand frequently as antagonistic-hypertensive. It is a L- type calcium channel blocker (CCB). There were only a few analogical inconsistencies 'tween Nifedipine's clinical manufacturing report and chemical analysis of solubility. By the words of pharmacology books it is a lipophilic substance. But loyal logical question before arises about how being a lipophilic stuff it can be secondhand in pregnancy confusions like eclampsia and pre-eclampsia without causing some hypotensive crisis in the increasing foetus. The ambition of this research search out conduct a re-check and proper calculation of partition co-efficient (logP) of Nifedipine and purify such discrepancy and improve if any mechanics miscalculation during allure property proof after finding. The method used is the “gold standard” quiver-flask procedure followed by analysis utilizing UV-spectrophotometry.
Author(s) Details:
Soham Samajpaty,
Department of General Medicine, International
Faculty, Russian National Research Medical University Named after NI Pirogov,
Moscow, Russian Federation.
Please see the link here: https://stm.bookpi.org/NAPR-V2/article/view/10600
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