Being key fundamental units for various normal products and exempt scaffolds in medicinal chemistry, functionalized (tetrahydro) quinoline particles, especially 2,4-diaryl (tetrahydro)quinoline derivatives tell a wide range of potent, interesting pharmacological ventures, and unique physicochemical properties. Their artificial method is based on the three-component Povarov response, in which commercially free substituted anilines and benzaldehydes are involved. The third component, trans (E)-methyl-isoeugenol, an triggered dienophile, comes from the essential oil of P. pseudocaryophyllus- (E)-methyl-isoeugenol chemotype- plant, or from eugenol, another phenolic metabolite of the divided oils. In this chapter, we explain the synthesis of some 4-(3,4-dimethoxyphenyl)-3-methyl-2-phenyl-1,2,3,4-tetrahydroquinolines that have happened prepared through the Povarov reaction, and their conversions (N-furoylation reaction and oxidative dehydrogenation aromatization response) which led to the establishment of new (tetrahydro)quinoline derivatives with alkaloid form. Intermediate and final products appealing biological models for pharmacological power research, especially regarding anticancer and decontaminating or antifungal drug design.
Author(s) Details:
Vladimir V. Kouznetsov,
Laboratorio de Química Orgánica y Biomolecular,
Universidad Industrial de Santander, Bucaramanga, Colombia.
Please see the link here: https://stm.bookpi.org/NACB-V2/article/view/10663
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