(E)-Methyl-Isoeugenol as a Natural Dienophile for the Povarov Reaction Conducting to the Alkaloid-Like 2,4-Diaryl-Tetrahydroquinolines Formation | Chapter 5 | Novel Aspects on Chemistry and Biochemistry Vol. 2

 Being key fundamental units for various normal products and exempt scaffolds in medicinal chemistry, functionalized (tetrahydro) quinoline particles, especially 2,4-diaryl (tetrahydro)quinoline derivatives tell a wide range of potent, interesting pharmacological ventures, and unique physicochemical properties. Their artificial method is based on the three-component Povarov response, in which commercially free substituted anilines and benzaldehydes are involved. The third component, trans (E)-methyl-isoeugenol, an triggered dienophile, comes from the essential oil of P. pseudocaryophyllus- (E)-methyl-isoeugenol chemotype- plant, or from eugenol, another phenolic metabolite of the divided oils. In this chapter, we explain the synthesis of some 4-(3,4-dimethoxyphenyl)-3-methyl-2-phenyl-1,2,3,4-tetrahydroquinolines that have happened prepared through the Povarov reaction, and their conversions (N-furoylation reaction and oxidative dehydrogenation aromatization response) which led to the establishment of new (tetrahydro)quinoline derivatives with alkaloid form. Intermediate and final products appealing biological models for pharmacological power research, especially regarding anticancer and decontaminating or antifungal drug design.

Author(s) Details:

Vladimir V. Kouznetsov,
Laboratorio de Química Orgánica y Biomolecular, Universidad Industrial de Santander, Bucaramanga, Colombia.

Please see the link here: https://stm.bookpi.org/NACB-V2/article/view/10663

Cranberry Polyphenols and Prevention against Urinary Tract Infections: A Brief Review | Chapter 13 | Current Advances in Chemistry and Biochemistry Vol. 4

 Cranberry (Vaccinium macrocarpon) is a unique source of polyphenols in the form of flavonoids and phenolic acids that has been shown to have antibacterial properties against urinary tract infections (UTIs), the second most common type of infection in the world. Due to high rates of recurrence and antibiotic resistance, UTIs may cause significant morbidity, particularly in healthy females. Antibiotic replacements for prophylaxis and treatment of urinary tract infections (UTIs) are constantly being sought. In contrast to cranberry, which has long been used to prevent UTIs in traditional medicine, Probiotics have emerged as a new alternative to antibiotics in the treatment of these infections, and they are the subject of new research. Other etiological agents, such as Klebsiella pneumoniae or Gram-positive bacteria from the Enterococcus and Staphylococcus genera, appear to be more widespread than previously thought. Current research is also focusing on the mechanisms behind the UTI-protective effects of cranberry, probiotics, and their new combined formulations, which are still being unraveled. In this paper, all of these current topics in the understanding of cranberry's protective effects against UTIs are reviewed. Finally, the evidence for probiotics and their combinations with cranberry in the treatment of UTIs is insufficient to draw any conclusions, but they appear to be a promising strategy for future treatments.

Author (s) Details

Dolores González de Llano
Institute of Food Science Research (CIAL), CSIC-UAM, Nicolás Cabrera, 9, Campus de Cantoblanco, 28049 Madrid, Spain.

M. Victoria Moreno-Arribas
Institute of Food Science Research (CIAL), CSIC-UAM, Nicolás Cabrera, 9, Campus de Cantoblanco, 28049 Madrid, Spain.

Begoña Bartolomé
Institute of Food Science Research (CIAL), CSIC-UAM, Nicolás Cabrera, 9, Campus de Cantoblanco, 28049 Madrid, Spain.

View Book :- https://stm.bookpi.org/CACB-V4/article/view/913