A Novel UPLC Method Development and Validation of Mirabegron Determination in Pharmaceutical Dosage Forms | Chapter 10 | Novel Aspects on Pharmaceutical Research Vol. 2

 The main aim concerning this investigation search out develop an accurate, natural and fast Ultra-Performance Liquid Chromatography (UPLC) method for the decision of Mirabegron in pharmaceutical dosage forms Mirabegron is a drug that eases the manifestations of overactive pouch. Mirabegron activates the β3 adrenergic receptor in the bladder's detrusor muscle, leading to muscular entertainment and bladder capacity growth. There have been any measurement methods found, however they are burdensome and time absorbing. The amount of Mirabegron in pharmaceutical dosage forms was driven using a natural, exact, precise and useful UPLC method that was established in the current study. On Acquity BEH C18 (50*3.0mm. 1.7m), chromatographic break-up was achieved by the isocratic elution style using movable phase holding Potassium di hydrogen phosphate: Methanol (70:30) v/v with a UV detection awareness of 254 nm. Validation of the developed UPLC plan was done as per the guidelines of the International Conference on Harmonization in agreements of system rightness, precision, accuracy, precision, sensitivity, distance, and robustness.

Author(s) Details:

B. Anupama,
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India.

A. Viswanath,
Vignan Pharmacy College, Vadlamudi-522 213, Guntur (Dt), A.P, India.

. Azizunnisa,
University of Hail, Hail, Saudi Arabia.

Md. Vaseemunnisa,
KVSR Siddhartha College of Pharmaceutical Sciences, Vijayawada-520010, Andhra Pradesh, India.

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