The present study proposed to investigate the antiepileptic exercise of fluoro substituted benzothiazole derivatives (FBTDs) in exploratory induced epilepsy in rodent. The investigation of new antiepileptic drugs is the study of artificial compounds that may concern new structural classes and exhibit attractive effects with more advantageous effects than existent drugs. Epilepsy is a tendency to have repeating seizures. It can affect one, at any age, from any line of work. It is one of ultimate common weighty neurological environments. The acute spoken toxicity was determined as per OECD guideline 423 and minimum direct dose was still determined for pharmacological hide. The antiepileptic activity of FBTDs was intentional against maximal electroshock (MES) and strychnine (1 mg/kg, s. c.) inferred seizures in mice. In MES test, the event of tonic posterior limb enlargement was significantly reduced by all FBTDs at a prescription of 100 mg/kg except, P-3, and OX-9 whereas in strychnine persuaded model, the seizure abeyance was sustained by all FBTDs at a shot of 100 mg/kg except P-4. P-7 and OX-9. The novels synthesized FBTDs exhibit anticonvulsant venture, The ticonvulsant action of FBTDs is better against strychnine induced seizures than MES seizures. P-1, P-2, P5 and P-9 were proved significant anticonvulsant endeavor against both MES and strychnine persuaded models.
Author(s) Details:
I. Shanmukha,
PG Department of Pharmacology, SCS College of
Pharmacy, Harapanahalli, Davangere 583131 Karnataka, India.
M.
Vijay Kumar,
PG
Department of Pharmacology, SCS College of Pharmacy, Harapanahalli, Davangere
583131 Karnataka, India.
E. Jayachandran,
PG Department of Pharmacology, SCS College of Pharmacy, Harapanahalli,
Davangere 583131 Karnataka, India.
B. C. Revanasiddappa,
Department of Pharmaceutical Chemistry, NGSM Institute of Pharmaceutical
Sciences. Paneer, Deralakatte, Mangalore 575018 Karnataka, India.
Please see the link here: https://stm.bookpi.org/NAPR-V2/article/view/10598
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