Promising Anti-mycobacterial Potentiality of Indian Noteworthy Plant Argemone mexicana Linn. | Chapter 2 | Pharmaceutical Science: New Insights and Developments Vol. 4

The emergence of multi-drug resistant (MDR) and extensive drug-resistant strains of mycobacterium increases the complications in the treatment of Tuberculosis. Due to this serious problem, there is an urgent need to find newer anti-TB agents to overcome this problem. Medicinal plants offer hope for developing alternative medicine for the treatment of TB. The plant contains a large number of alkaloids, terpenoids, flavonoids, steroids, gallic acid, tannin, tannic acid, reducing sugar, all carbohydrates, glycosides, steroids, saponins, phenols, proteins and amino acids. Many of these exhibit antibacterial, anti-inflammatory, and also immunomodulatory effects. The plants from Ayurveda have been successfully used for the treatment of TB and have less toxicity and side effects as compared to allopathic medicines. The present investigation was carried out to determine the anti-mycobacterium activity of Argemone Mexicana Linn. The MIC of the plant extract was performed using the broth microdilution assay method, and Rifampicin and Isoniazid (10µg/ml), were used as reference standards.  The result suggests that the methanol extract could be a rich source of natural anti-tubercular agents showing the highest zone of inhibition against the strain Mycobacterium tuberculosis (MTCC-300) M.pheli (MTCC-1723) and M.avim (MTCC-1724) i.e.  38+1.2 mm 13.5+1.2 mm and 23.4+3.1 mm respectively.

 

Author (s) Details

 

Yelmate A. A
Department of Pharmaceutics, Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Narayanpure D.V
Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Suryawanshi S.D
Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Nisale A.D
Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v4/4643

Screening of Antituberculosis Drugs by Thin Layer Chromatography: Experimental Investigation | Chapter 11 | Novel Aspects on Chemistry and Biochemistry Vol. 1

 Tuberculosis resumes to be a main public health issue in underdeveloped countries. In South Asian countries TB is a very universal and prevalent ailment and most of the treatment programmes are controlled directly through administration agencies and emergency rooms. In this study, a novel thin-layer chromatographic screening approach for the labeling of rifampicin, isoniazid, and pyrazinamide in pharmaceutical dosages was manifested. The solvent scheme used to determine these three drugs was (propanol: hexane: ethyl acetate: liquid) (5:2:1.7:0.2 v/v) and the Rf value of rifampicin, pyrazinamide and isoniazid was 0.68, 0.74 and 0.50, individually. The developed arrangement for retention determinant had intra-epoch and inter-era repeatability with a predictable difference (SD) of about 0.5-1.0%.

Author(s) Details:

Abhilasha Durgbanshi,
Department of Chemistry, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar-470 003, India.

Devasish Bose,
Department of Criminology and Forensic Science, Dr. Harisingh Gour Vishwavidyalaya (A Central University), Sagar-470 003, India.

Please see the link here: https://stm.bookpi.org/NACB-V1/article/view/10440Z

Use of Rifampicin as a Recent Advancement in Treatment of Resistant and Severe Cases of Intrahepatic Cholestasis of Pregnancy for Better Fetal Outcome| Chapter 5 | Perspective of Recent Advances in Medical Research Vol. 7

Background: High levels of estrogen and progesterone before birth are involved in immoral green light of bile acids from liver superior to elevated antitoxin hostility acids in Intrahepatic Cholestasis of gestation (ICP). Its main manifestation is pruritus and weak fetal effect is worrisome of it. Ursodeoxycholic acid (UDCA) leads to relaxation in this place pruritus and threatening of antitoxin bile acids, through lowering before birth obstacles in the way that preterm beginning, stillbirth and meconium-tainted liquor.Methods: This affiliate is established a potential study attended at a after second care hospital connected with university in Bihar, India. 108 girls were included in this place study, place all were started on spoken UDCA. Satisfactory remedy in pruritus was stated by 78 subjects the one were described as group A. Remaining 30 were likely Rifampicin apart from UDCA, and they were named Group B. Both groups were distinguished for before birth outcomes, style and organize of beginning.Results: The mathematical, obstetric and healing limits were corresponding for both the groups. The mean (Standard Deviation = SD) gestational age at transfer was 37.011 (1.18) weeks camp A and 35.70 (2.57) weeks camp B [p advantage = 0.012]. 63.0% (46) and 50% (15) babies camp A and B individually were born adequate-term and 37.0% (27) gang A and 50% (15) camp B were innate preterm [p worth = 0.222]. Spontaneous preterm transmittal was visualized in 17.8% of group A study subjects and 26.67% parties gang B [p profit = 0.310]. Rate of Neonatal Unit (NNU) admittance was 35.9% and 50% individually for neonates innate to Group A and Group B players [p value = 0.182]. There was no important dissimilarity in the antagonistic before birth/neonatal consequence and still beginning rates {9% against 6.7% in groups A & B individually} [p advantage = 0.722]. There was no meaningful distinctness betwixt two together groups in terms of the allocation of the fashion of transfer (X2 = 3.380, p = 0.337).Conclusion: Addition of Rifampicin is occasionally wanted in inmates accompanying earlier attack of ICP the one do not acknowledge convincingly to UDCA. Using this drug as an addition to UDCA does not bring about weak feto-maternal effect.

Author(s) Details:

Manoj Kumar,
Department of Pediatrics, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.

. Swati,
Department of Obstetrics & Gynecology, All India Institute of Medical Sciences, Deoghar, Jharkhand, India.

Anjali Kumari,
Department of Obstetrics & Gynecology, Anugraha Narayan Medical College & Hospital, Gaya, Bihar, India.

Avinash Kumar,
Department of Medicine, All India Institute of Medical Sciences, Patna, Bihar, India.

Please see the link here: https://stm.bookpi.org/PRAMR-V7/article/view/9316