Promising Anti-mycobacterial Potentiality of Indian Noteworthy Plant Argemone mexicana Linn. | Chapter 2 | Pharmaceutical Science: New Insights and Developments Vol. 4

The emergence of multi-drug resistant (MDR) and extensive drug-resistant strains of mycobacterium increases the complications in the treatment of Tuberculosis. Due to this serious problem, there is an urgent need to find newer anti-TB agents to overcome this problem. Medicinal plants offer hope for developing alternative medicine for the treatment of TB. The plant contains a large number of alkaloids, terpenoids, flavonoids, steroids, gallic acid, tannin, tannic acid, reducing sugar, all carbohydrates, glycosides, steroids, saponins, phenols, proteins and amino acids. Many of these exhibit antibacterial, anti-inflammatory, and also immunomodulatory effects. The plants from Ayurveda have been successfully used for the treatment of TB and have less toxicity and side effects as compared to allopathic medicines. The present investigation was carried out to determine the anti-mycobacterium activity of Argemone Mexicana Linn. The MIC of the plant extract was performed using the broth microdilution assay method, and Rifampicin and Isoniazid (10µg/ml), were used as reference standards.  The result suggests that the methanol extract could be a rich source of natural anti-tubercular agents showing the highest zone of inhibition against the strain Mycobacterium tuberculosis (MTCC-300) M.pheli (MTCC-1723) and M.avim (MTCC-1724) i.e.  38+1.2 mm 13.5+1.2 mm and 23.4+3.1 mm respectively.

 

Author (s) Details

 

Yelmate A. A
Department of Pharmaceutics, Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Narayanpure D.V
Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Suryawanshi S.D
Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Nisale A.D
Dayanand Education Society’s, Dayanand College of Pharmacy, Brashi Road Latur, Maharashtra, India.

 

Please see the book here:- https://doi.org/10.9734/bpi/psnid/v4/4643

Design, Synthesis, and Anti-Tubercular Studies of 10-(phenylsulfonyl)pyrimido[1,2-a]benzimidazol (10H) One Derivatives | Chapter 7 | New Innovations in Chemistry and Biochemistry Vol. 3

 Sulfonamides are a special class of chemicals with outstanding antibacterial properties. Sulpha medicines were the first efficient chemotherapeutic agents used to treat bacterial infections in humans, and they were shown to be resistant to Mycobacterium tuberculosis, Typhoid and Paratyphoid bacilli, and other germs. N-sulfonation of 2-substituted-pyrimido[1,2- a]benzimidazol-4(10H)-ones yielded a series of new 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2- a]pyrimidin-4-one derivatives, which were evaluated for in vitro anti-tuberculosis activity against Mycobacter

Author(S) Details

K. V. Jagannath
Department of Chemistry, Bengaluru City University, Central College Campus, Bengaluru-560001, India.

G. Krishnamurthy
Department of Chemistry, Bangalore University, Jnanabharathi Campus, Bengaluru-560056, India.

View Book:- https://stm.bookpi.org/NICB-V3/article/view/4011