Showing posts with label sulfonamide. Show all posts
Showing posts with label sulfonamide. Show all posts

Thursday, 14 March 2024

A Review on Transient Drug-Induced Myopia | Chapter 12 | Recent Updates in Disease and Health Research Vol. 3

Myopia is the most common eye disease and is one of the leading causes of vision impairment worldwide. It (nearsightedness) is a refractive error, a condition in which the cornea and lens of the non-accommodating eye have too much plus power for the length of the eye. As a result, images of distant objects are focused in front of the retina and thus appear blurred. Transient drug-induced myopia is a myopia induced by a drug as a transient side effect. Several case reports of transient drug-induced myopia have been reported. An adverse drug reaction is an expression that describes harm associated with the use of a given medication at a normal dosage during normal use. These cases have been associated with secondary angle closure glaucoma and other ocular conditions such as choroidal detachment, maculopathy, and retinal folds. Drugs known to produce this effect include sulfa drugs and other medications. The possible mechanism is thought to be an allergic reaction to the drug. Both ciliary muscle contraction and ciliary body edema may play a role in the Patho mechanism. Differential diagnosis is made with a number of conditions, either ocular in origin or associated with an underlying systemic cause. Discontinuation of medications leads to complete resolution of the anatomic shift.


Author(s) Details:

Kaimbo DKW,
Department of Ophthalmology and Biophysics, University of Kinshasa, Congo.

Please see the link here: https://stm.bookpi.org/RUDHR-V3/article/view/13714

Thursday, 30 September 2021

Design, Synthesis, and Anti-Tubercular Studies of 10-(phenylsulfonyl)pyrimido[1,2-a]benzimidazol (10H) One Derivatives | Chapter 7 | New Innovations in Chemistry and Biochemistry Vol. 3

 Sulfonamides are a special class of chemicals with outstanding antibacterial properties. Sulpha medicines were the first efficient chemotherapeutic agents used to treat bacterial infections in humans, and they were shown to be resistant to Mycobacterium tuberculosis, Typhoid and Paratyphoid bacilli, and other germs. N-sulfonation of 2-substituted-pyrimido[1,2- a]benzimidazol-4(10H)-ones yielded a series of new 10-phenylsulfonyl-2-substituted-4,10 dihydrobenzo[4,5]imidazo[1,2- a]pyrimidin-4-one derivatives, which were evaluated for in vitro anti-tuberculosis activity against Mycobacter


Author(S) Details

K. V. Jagannath
Department of Chemistry, Bengaluru City University, Central College Campus, Bengaluru-560001, India.

G. Krishnamurthy
Department of Chemistry, Bangalore University, Jnanabharathi Campus, Bengaluru-560056, India.

View Book:- https://stm.bookpi.org/NICB-V3/article/view/4011