The goal of the current study is to create and assess omeprazole magnesium delayed release pellets for the treatment of acid reflux and ulcers utilising the drug stacking approach with a fluid bed processor.
Omeprazole magnesium saturated solutions in a variety of
non-volatile solvents, including methanol, ethanol, acetone, isopropanol, and
water, were prepared for solubility tests. Purified water, pH 6.8 and pH 7.4
phosphate buffers were also used to test the drug's solubility in these
solvents. Omeprazole magnesium delayed release pellets were created by using a
fluid bed processor to modify the compositions of the drug loading, barrier
coating, and enteric coating. Due to the dissolving profile of formulation
(F8), which comprises an efficient amount of hydroxypropyl cellulose-L and
eudragit-L30 D55, the medication is released effectively in 30 minutes. FTIR
and DSC tests were conducted to show that the modified formula was not
incompatible with the medication and excipients. SEM research was done to
comprehend the surface morphology of the pellets. Due to the existence of an
ester structure, the enteric polymer eudragit was susceptible to hydrolysis in
humid environments, which had an impact on the enteric defence in acid media.
Author(s) Details:
Varalakshmi Mummidi,
School of Pharmaceutical Sciences and Technologies, Jawaharlal Nehru
Technological University Kakinada, East Godavari District-533003, Andhra
Pradesh, India.
Shaikh Rezwana,
School of Pharmaceutical Sciences and Technologies, Jawaharlal Nehru
Technological University Kakinada, East Godavari District-533003, Andhra
Pradesh, India.
Please see the link here: https://stm.bookpi.org/CAPR-V5/article/view/7770
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