The Spectrum of Congenital Heart Defects in Infants with Down’s Syndrome, Khartoum, Sudan: A Cross-Sectional Descriptive Study | Chapter 10 | Recent Developments in Medicine and Medical Research Vol. 9

 Using immunohistochemistry for NA, dopamine—hydroxylase (DBH), dopamine (DA), and tyrosine hydroxylase, the location and chemical nature of neurons immunoreactive to noradrenaline (NA) in the cat dorsal vagal complex (DVC) were investigated under various situations. In non-treated animals, the location of NA-immunoreactive (-ir) and DBH-ir neurons was largely overlapping. They were predominantly discovered in the nucleus of solitary tract (NTS), with a few in the dorsal motor nucleus of the vagus. The bulk of NA-ir / DBH-ir neurons were found in the commissural and ventral subnuclei of NTS. In the area postrema, a limited number of weakly stained NA-ir cell bodies coexisted with numerous brightly marked DBH-ir cell bodies. The injection of pargyline, a monoamine oxidase inhibitor (MAOI), increased NA immunoreactivity and the quantity of DVC cells and axons. After treatment with MAOI + parachlorophenylalanine, an inhibitor of tryptophan and phenylalanine hydroxylases, both DA and NA immunoreactivities were dramatically reduced in a large number of axons, while NA immunoreactivity in DVC cell bodies remained visible. NA immunoreactivity was enhanced solely in cell bodies in the areas specified above, where NA and DBH immunoreactivity was weak or undetectable. The physiological repercussions were examined using prior reports as a reference.

Author(S) Details

Osama El-Shazali
Department of Paediatrics, University of Khartoum, Sudan.

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