Role of Reactive Oxygen Species in Signaling Feeding Behaviour | Chapter 11 | Recent Developments in Medicine and Medical Research Vol. 9

 Reactive oxygen species (ROS) are not merely by-products of substrate oxidation when they are produced transiently and modestly; they are also molecules engaged in intracellular signalling. The goal of this review is to look into how reactive oxygen species influence feeding behaviour through intracellular signalling. Reactive oxygen species are generated predominantly through mitochondria and, to a lesser extent, through NADPH oxidases, by substances like glucose and lipids. The level of ROS generated in hypothalamic neurons such as NPY/AgRP and POMC neurons is directly influenced by substrate level, and as a result, downstream neurons in other parts of the hypothalamus such as the ventromedial nucleus (VMN), the paraventricular nucleus (PVN), and the lateral hypothalamus are affected. The activation of the POMC neuronal population is triggered by an increase in ROS levels, whereas the NPY/AgRP neurons are triggered by a reduction in ROS levels. The activation of these neurons impacts feeding behaviour, which can range from satiety to increased food intake depending on whether POMC neurons or NPY/AgRP neurons are active.

Author(S) Details

John Amote Lyngdoh
Department of Physiology/Pharmacology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Julie B. Wahlang
Department of Physiology/Pharmacology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Banylla Nongkynrih
Department of Physiology/Pharmacology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Merrycka A. Sangma
Department of Physiology/Pharmacology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

Reuben Syiem
Department of Physiology/Pharmacology, North Eastern Indira Gandhi Regional Institute of Health and Medical Sciences, Shillong, Meghalaya, India.

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