The goal of this work was to identify secondary metabolites in an ethanol extract of Copaifera luetzelburgii Harms barks (EEtOH-Cl), as well as assess its antioxidant potential in vitro and reproductive toxicity in rats. Anthocyanidins, anthocyanins, auronas, chalcones, flavanones, flavanonóis, flavonols, leucoanthocyanidins, xanthones, strong fixed acids, and saponins were found in the phytochemical investigation. The antioxidant activity in vitro was tested using thiobarbituric acid, nitrite, and radical hydroxyl to produce reactive species, which showed antioxidant activity for these parameters. The number, morphology, functional viability, and histopathology of spermatozoa were used to assess subchronic toxicity. It was discovered that at doses of 125 and 250 mg/kg, mitochondrial activity was reduced, as well as acrosome integrity. There were no morphological or histopathological changes, but histomorphometry of the seminiferous tubules revealed a size reduction of the tubular diameter and height of the germinal epithelium.
Author(S) Details
Jeorgio Leão Araújo Federal
Medicinal Plants Research Center, Federal University of Piauí, CCS, Brazil.
Maria Zenaide de Lima Chagas Moreno Fernandes
Biochemistry and Pharmacological Department, Federal University of Piaui, CCS, Brazil.
Sidney Gonçalo de Lima
Organic Geochemistry Laboratory, Federal University of Piauí, Teresina, Brazil.
Marcelo Costa dos Santo
Organic Geochemistry Laboratory, Federal University of Piauí, Teresina, Brazil.
Silvana Maria Medeiro de Sousa Silva
Animal Surgery and Clinical Department, Federal University of Piaui, CCA, Brazil.
Marlon de Araújo Castelo Branco
Northeast Biotechnology Network, Federal University of Piaui, CCA, Brazil.
Rozeverter Moreno Fernandes
Veterinary Morphophysiology Department, Federal University of Piaui, CCA, Brazil.
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