The goal of this chapter is to decipher a number of theoretical inconsistencies that contradict the concept of host immunological defence against spontaneous cancer. It's as follows: Non-selective cancer cytotoxic therapy is effective, but it is harmful to the host; legal deep lymphocytopenia, i.e., immunosuppression, follows conventional cytotoxic therapy; a high risk of new malignancies follows it as well; malignant cells prefer to spread through lymph nodes, which are favourite checkpoints for immunity; accepted anti-angiogenic treatment restricts immunocytes' access inside a tumour. We concluded that the development of a tumour and its vessels, gradual exhaustion of hematopoietic stem cell number in blood and emergence of cancer cachexia, a ratio of infectious morbidity and cancer mortality in their interrelation, extracted from experimental, clinical data, and population statistics, that the aforementioned and other discrepancies become regularities if the cells renew in both directions.
Author (S) Details
A. N. Shoutko
Laboratory for Improvement of the Cancer Treatment Methods, Russian Granov’s Research Center for Radiology and Surgical Technologies, Ministry of Health Care of the Russian Federation, Russia.
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