To test the principle of indirect tumour control based on morphogenic cell distraction, 114 patients with advanced ovarian carcinoma (stage III-56, stage IY-21, relapse 37) were treated with subtotal half-body (low part) irradiation at low doses (0,1 Gy x 10 for 3 weeks or 3Gy x 3 daily), and the results were compared to those of 190 patients (stage III-66, stage IY-21, relapse 37) who received (2 Gy x 23 daily). In both groups, the surgical and chemotherapy components were equalised. In comparison to traditional local radiotherapy, low dosage half body irradiation resulted in 34 percent and 11 percent 5-year survival for initial and relapsed patients, respectively (7 percent and 0 percent ). It is concluded that experimentally induced reparation/regeneration processes in cancer host normal tissues are capable of competing remotely with tumour for morphogenic/feeding cells derived from bone marrow and circulating in the circulation.
Author(s)
Details
A. N.
Shoutko
Laboratory for Improvement of the Cancer Treatment Methods, Russia.
L. E.
Yurkova
Devision of Gynecological Oncology, Russia.
K. S.
Borodulya
Devision of Gynecological Oncology, Russia.
L. P.
Ekimova
Laboratory for Improvement of the Cancer Treatment Methods, Russia.
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