Ovarian sarcomas are extremely rare tumours with a dismal prognosis. Surgical treatment is primarily based on debulking procedures used in epithelial ovarian cancer, whereas chemotherapy is based on data extrapolated from research in sarcomas of various primary sites. In the second-line situation, trabectedin has been established as a standard of care for the treatment of soft-tissue sarcomas. There are currently no randomised clinical trials that support a specific maximum number of trabectedin cycles for any gynaecological sarcoma. Furthermore, there is limited evidence in the literature that trabectedin administration in haemodialyzed individuals is feasible and safe. The case of a 48-year-old woman with metastatic high-grade undifferentiated sarcoma of the right ovary is presented in this report. She had primary surgery and first-line chemotherapy with doxorubicin and ifosfamide, and after cycle three, she achieved a partial response. Treatment tolerance was poor, with hematologic and non-hematologic toxicities ranging from grade 3 to 4, including the development of chronic renal failure necessitating permanent haemodialysis. Treatment was switched to trabectedin, which resulted in a full response that has lasted for almost four years, with fifteen months off-treatment. In a hemodialyzed patient, our case demonstrates the safety of long-term trabectedin administration with the accomplishment of a lasting full disease response in the metastatic situation.
Author(s) Details
Efthymiadis,
Konstantinos
Department of Medical Oncology, Aristotle University of Thessaloniki,
“Papageorgiou” General Hospital, Nea Efkarpia, Thessaloniki, Greece.
Adamidis, Christos
Department of Medical Oncology, Aristotle University of Thessaloniki,
“Papageorgiou” General Hospital, Nea Efkarpia, Thessaloniki, Greece.
Koukoutzeli,
Chrysanthi
Department of Medical Oncology, Aristotle University of Thessaloniki,
“Papageorgiou” General Hospital, Nea Efkarpia, Thessaloniki, Greece.
Tzelepi, Vassiliki
Department of Medical Oncology, Aristotle University of Thessaloniki,
“Papageorgiou” General Hospital, Nea Efkarpia, Thessaloniki, Greece.
Timotheadou, Eleni
Department of Medical Oncology, Aristotle University of Thessaloniki,
“Papageorgiou” General Hospital, Nea Efkarpia, Thessaloniki, Greece.
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