Determination of Clinical Profile and Causality of Cutaneous Adverse Drug Reactions among Patients Attending Tertiary Care Teaching Hospital in South India | Chapter 15 | New Frontiers in Medicine and Medical Research Vol. 12

 Background: A cutaneous adverse drug reaction (CADR) is any unfavourable alteration in the structure or function of the skin and its appendages that is caused by a drug eruption, regardless of the cause. CADRs have a wide range of morphological patterns, ranging from minor urticaria to life-threatening forms including SJS and TEN vasculitis. CADRs (non-severe CADRs) and CADRs (severe CADRs) are the terms used to describe them. In this new era of enhanced multi-drug research, identifying the causative drug is a difficult task, but it can help prevent additional problems and create safer treatments. The purpose of this study was to establish the clinical profile and aetiology of CADR in patients in a Hyderabad tertiary care hospital. Methods: Patients attending the dermatological OPD of a medical college and hospital in Hyderabad participated in a 6-month observational hospital-based study. The study included patients with suspected drug-related cutaneous lesions, and the substance responsible for the lesions was identified. The Indian National Pharmacovigilance Programme recommended a framework for recording recent drug history, and causality was evaluated using WHO-Uppsala Monitoring Centre (WHO-UMC) standards. The study population consisted of 52.4 percent males and 52.4 percent females (47.6 percent ). The majority of them were in their fifties and sixties. The most common CADR patterns were urticaria (19.05%), erythema multiforme (17.46%), and morbilliform rash (17.46%). (17.46 percent ). Antibiotics (39%) were the most usually prescribed drugs, followed by NSIADs (26%), and ATT (26%). (18 percent ). Conclusions: CADRs generate significant morbidity in industrial workers, both severe and non-severe, and the necessity of pharmacovigilance should be emphasised even more to prevent such events. The need of the hour is to use skin tests and dermatoscopy to promptly identify such reactions.

Author(s) Details

Archana Mavoori
Department of Dermatology, ESIC Medical College, Hyderabad, Telangana, India.

Sudha Bala
Department of Community Medicine, ESIC Medical College, Hyderabad, Telangana, India.

Sneha Pamar
Department of Dermatology, ESIC Medical College, Hyderabad, Telangana, India.

Karunasree Podila
Department of Pharmacology, ESIC Medical College, Hyderabad, Telangana, India.

Deepthi Sriram
Department of Dermatology, ESIC Medical College, Hyderabad, Telangana, India.

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