Background: Ulcerative conditions are widespread, affecting about 25% of younger generations, including children and young adults, necessitating immediate intervention. Pure nicotine is one of the topical treatments that can be used to treat mouth ulcers. It's an alkaloid generated from and found in Solanaceae plants that works by suppressing the inflammatory system. Pure nicotine's medicinal significance in the treatment of oral ulcers has been investigated, and it has been found to be helpful in lowering pain and ulcer erythema. Gel-based topical preparations appear to be the most appropriate conduit for administering local medication therapy to the oral cavity. Pentoxifylline is an anti-inflammatory xanthine derivative that has just been licenced for the treatment of peripheral artery disease. It also has an anti-tumor necrosis factor (TNF) impact, reverses fibroblast proliferation, and may help to reduce the discomfort and duration of mouth ulcers. The goal of this research is to identify the histological evaluation of the effect of pure nicotine and pentoxifylline gel on oral ulcers. Materials and Procedures: In this investigation, 36 male Albino rats weighing 200–250 grammes were employed. In the entire rat population, oral ulcers were produced in the right buccal mucosa. The rat population was split into three groups, each with twelve rodents. On the ulcers, pure nicotine, pentoxiphylline gel, and placebo were applied four times daily to each group. At days two, four, and eight, four rats from each group were slaughtered, and the right cheek mucosa was excised and processed for histological investigation. Results: The ulcers in the pure nicotine group healed entirely with no signs of inflammation and a rise in keratinization by day 8, but the ulcers in the pentoxiphylline group did not heal completely or produce any keratinization when compared to the nicotine group. From day 2 to day 8, the control group experienced severe ulceration and irritation.
Author(s) Details
Soha Basha
Department of Oral Medicine, Diagnosis and Radiology, Basic Dental
Sciences, College of Dentistry/ Princess Nourah Bint Abdulrahman University,
Riyadh, Saudi Arabia.
Hazar Al-Harbi
Department of Oral Pathology, Basic Dental Sciences, College of Dentistry/
Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Sahar El-Refai
Department of Oral Pathology, Basic Dental Sciences, College of Dentistry/
Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
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