Background: Cytomegalovirus (CMV)
infection is common among HIV-infected individuals. Its
contribution to morbidity and mortality
became more apparent following introduction of highly active
antiretroviral therapy (HAART) which
improved survival among HIV-infected individuals.
Objectives: This study aimed at
determining the prevalence of both active and latent CMV infections
among HIV-infected individuals on HAART
in Ilorin, Nigeria.
Methods: A total of 360 consented
HIV-1 patients were recruited for the study. About 5 ml of blood
and sociodemographic data were collected
from each patient. Plasma from the blood was tested for
anti-CMV IgM and IgG presence using
ELISA.
Results: Of the 360 participants
tested, 42 (11.7%) and 265 (73.6%) were respectively anti-CMV IgM
and IgG antibodies positive representing
active and latent infection rates respectively. Gender and
age were the correlates of IgM
seropositivity while age, occupation and marital status correlated with
IgG seropositivity. Occupation, marital
status, use of HAART and CD4+ count were not statistically
associated with IgM level while gender,
use of HAART and CD4+ count did not correlate with IgG
level.
Conclusions: This study has
demonstrated high level of latent and active CMV infection among
HAART recipients in Ilorin and
highlighted the need for incorporation of antiherpes drugs in the
treatment regimen.
Author (s) Details
Augustine Udeze
Department of Microbiology,
Virology Unit, University of Ilorin, P.M.B 1515 Ilorin, Nigeria.
Mutiat Odebisi-Omokanye
Department of Microbiology,
Infectious Disease, Environmental Health and Toxicity Research Group,
University of Ilorin, P.M.B 1515 Ilorin Nigeria.
Toluwani Ajileye
Department of Microbiology,
Virology Unit, University of Ilorin, P.M.B 1515 Ilorin, Nigeria.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/248
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