Cigarette smoking is the primary cause of lung cancer,
accounting for about 80% of cases. Lung cancer ranks second among cancer
diagnoses for both genders in the US and is the primary cause of cancer-related
deaths. The study aims to assess the role of liquid Biopsy and tumour-derived
biomarkers in diagnostic lung cancer. Numerous body fluids and tissues include
tumour-derived biomarkers for lung cancer, which offer important information
for diagnosis, prognosis, and treatment monitoring. These biomarkers consist of
tumour-derived exosomes, microRNAs (miRNAs), circulating tumour cells (CTCs),
and circulating tumour DNA (ctDNA). This study found that CTCs are tumour cells
that separate from primary or metastatic lesions and enter the peripheral
circulation on their own or as a consequence of a diagnosis or therapeutic
procedure. Moreover, Extracellular vesicles (EVs) are lipid-bound, nanoscale
particles secreted into the extracellular space by cells. Microvesicles (MVs),
exosomes, and apoptotic bodies are the three primary subtypes of extracellular
vesicles (EVs). Along with the cfDNA fraction contains DNA produced by tumour
cells after apoptosis, necrosis, or active secretion. With ongoing
advancements, liquid biopsy represents a transformative step toward precision
oncology, offering hope for improved outcomes through earlier detection, better
monitoring, and tailored therapy in lung cancer.
Author(s) Details
Gyanendra Singh
Department of Pathology, All India Institute of Medical Sciences (AIIMS),
Rajkot, Gujarat, India.
Tarang Patel
Department of Pathology, All India Institute of Medical Sciences (AIIMS),
Rajkot, Gujarat, India.
Kesha Rachani
Department of Pathology, All India Institute of Medical Sciences (AIIMS),
Rajkot, Gujarat, India.
Vishal Tayade
Grant Medical College and Sir J.J Group of Hospitals, Mumbai, Maharashtra
400008, India.
Please see the book here:- https://doi.org/10.9734/bpi/msraa/v9/6037
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