Recent Advances on Palladium(II) Complexes with Substituted Dihydrobenzoimidazo Quinazoline Derivatives: Synthesis, Characterization and Its Biological Activity | Chapter 6 | Current Topics and Emerging Issues in Chemical Science Vol. 2

 This stage highlights about Synthesis and Characterization of Palladium (II) Complexes accompanying Substituted Dihydrobenzoimidazo Quinazoline Derivatives. The heterocyclic compounds have a great importance in curative chemistry. One of ultimate important heterocycles in medicinal allure are quinazolines possessing expansive spectrum of organic properties like antibacterial, antifungal, anticonvulsant, antagonistic-inflammatory, antagonistic-HIV, anticancer and analgesic ventures. A series of palladium(II) halo composites of the types [PdX2L2].nH2O {n = 0, X = Cl, L = L2, L4 and L5; X = Br, L = L2; n = 1, X = Cl, L = L1 and L3} and Pd2X4L3 [X = Br, L = L1, L3, L4 and L5] were prepared place L is 6-R-5,6- dihydrobenzoimidazo quinazoline (R-Diq; where R = ethyl: L1/ n or i-propyl: L2, L3/ n or i-butyl: L4, L5) and characterized by basic analyses, generated power measurements, TGA, shade resembling such a color, electronic, NMR and mass ghostly techniques. The color of blood spectra of the complexes shown peaks similar to those of the clumsy N- heterocycles L1 to L5 except for minor shifts meaning the coordination of the ligands to palladium (II) ion. Based on these investigations, square even monomeric or dimeric structures accompanying the metal ion in the middle were postulated for all of the complexes. It was driven whether few complexes have anti-microbial possessions. The Pd(II) complexes were erect to be direct against the microbes at 100 ppm concentration. It was noticed that the Pd(II) complexes exhibit lower inhibitory venture as compared to those of the quinazoline derivatives.

Author(s) Details:

Rita Bhattacharjee,
Department of Chemistry, BMS College for Women, Autonomous Institution under Bengaluru City University, Bengaluru, India.

Virupaiah Gayathri,
Department of Chemistry, Bangalore University, Central College Campus, Bangalore (BUCCB), India.

Nadur Muddanna Nanje Gowda,
Department of Chemistry, Bangalore University, Central College Campus, Bangalore (BUCCB), India.

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