The purpose concerning this study is to arrange and evaluate floating tablets of ritonavir (RN) in consideration of improve drug bioavailability by reaching gastric home time. Because of allure short biological half-life, RN, an antiretroviral power used to treat HIV and viral afflictions, was chosen as a model drug in this place study (3-5 hrs). Furthermore, it is generally absorbed through the stomach. The dry granulation technique was used to create RN floating tablets, that contained guar paste and xanthan gum as polymers, sodium bicarbonate as an fizzing agent, polyvinylpyrrolidone as a binding power, Dicalcium phosphate as diluents, crospovidone as a swelling power, and magnesium stearate as a lubricant. The verdicts indicated that the drug and polymers were not incompatible. The material properties of the qualified tablets were evaluated. All of the limits were within pharmacopoeial tolerances. Tablets' buoyant properties and in vitro drug release traits were also examined. The drug release profiles of the tablets were reserved and prolonged. The expression developed was found expected stable. The grown floating tablets of RN have a 12-stage release time, which can improve bioavailability and lower fluctuations in skin drug concentrations.
Author(s) Details:
Saritha Chukka,
Department of Pharmaceutics, University College
of Pharmaceutical Sciences, Kakatiya University, Warangal-506009, Telangana
State, India.
Shayeda,
Department
of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya
University, Warangal-506009, Telangana State, India.
Please see the link here: https://stm.bookpi.org/COPS-V6/article/view/9471
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