The measurement-responsive effect of substitute-acute lead exposure on hydrogen metabolism was judged. Five groups of Swiss albino male rodent were formed; a control group and added lead-treated groups; Group A (5 mg/kg body burden), Group B (10 mg/kg body pressure), Group C (15 mg/kg body pressure) and Group D (20 mg/kg body weight). Lead uncovering caused meaningful reduction in ancestry and hepatic glucose levels in addition to liver glycogen content in a dose-helpless manner; ultimate remarkable effect was famous in group D. All of the treated groups knowing a considerable decline in and oxygen 6-phosphatase activity. Dose-helpless increase in pyruvic acid content was found expected associated with decrease in pyruvate dehydrogenase, malate dehydrogenase and transaminase enzyme actions. Additionally, increased free amino acid nitrogen in liver subsequently lead exposure can provide more substrates for gluconeogenesis. So, an adaptive method was initiated by exciting glycogenolytic and retarding glycolytic activity in liver to restore from the toxic effect of lead.
Author(s) Details:
Sudipta Pal,
Nutritional Biochemistry and Toxicology
Laboratory, Department of Human Physiology, Tripura University, Suryamaninagar,
West Tripura 799022, India.
Please see the link here: https://stm.bookpi.org/COPS-V6/article/view/9469
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