The study's objectives were to identify the pattern of alterations in serum IgE and IgG levels and to assess their potential effects on the etiopathogenesis of acute myocardial infarction (AMI). Between September and December 1998, the Coronary Care Units (CCU) at the Seventh October Hospital in Benghazi, Libya, and the Jamahiriya Hospital in Benghazi, Libya, received a total of 31 AMI patients. An additional 26 healthy adult Libyans were collected as normal control (NC) participants, and a total of 11 patients with angina pectoris (AP) were obtained as disease controls. To obtain venous blood samples for use in routine haematological testing, biochemical analyses, and specialised immunological assays, tubes were filled with or without anticoagulants as needed. Both on the first day (AMI 1: 102.03.2, AP 1: 39.91.2, NC 1: 36.81.5, ANOVA: P=0.0001) and the seventh day (AMI 7: 119.83.7, AP 7: 37.11.6, NC 1: 36.81.5, ANOVA: P=0.0000), serum IgE levels (GMGSD, iu/ml) were substantially higher in AMI compared to AP and Between AP and NC as well as between AMI1 and AMI7, there were no discernible variations in IgE levels (P>0.05). Elevated serum IgE levels in AMI were unaffected by risk variables such streptokinase therapy, comorbidities, and history of previous coronary artery attacks (H/OP CAA), smoking, diabetes, or hypertension (P>0.1). AMI and AP both had significantly lower serum IgG levels (MeanSD, mg/dl) than NC on the first and seventh days (AMI1: 1033314, AP1: 1056320, NC: 1258251, ANOVA: P=0.0144, AMI7: 936383, AP 7:1042318, NC: 1258251, ANOVA, P=0.0002) IgG levels did not differ significantly between AMI1 and AP1 (P=0.833) or between AMI7 and AP7 (P=0.307). However, the difference between the IgG level at the 7th day and the first day was significant for AMI (P=0.014) but not for AP (P=0.859). IgG levels during the first and seventh days were substantially associated in both AP and AMI patients (r=0.658, P=0.028 and 0.764, P=0.000, respectively). High IgE levels in AMI patients may protect them against the effects of an infarction. To comprehend their role in the aetiopathogenesis of AMI, further study on IgG subclasses, as well as other immunological responses such IgG, complement, cytokines, and cellular immunity, is required.
Author(s) Details:
A. S. M. Giasuddin,
Departments of laboratory Medicine, Al-Arab Medical University, Benghazi, Libya.
Jamila M. ElMahdawi,
Departments of laboratory Medicine, Al-Arab Medical University, Benghazi, Libya.
Fakhri M. EI Hassadi,
Departments of Internal Medicine, Al-Arab Medical University, Benghazi, Libya.
Please see the link here: https://stm.bookpi.org/CODHR-V3/article/view/7896
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