Persistent Inflammation as a Cause of Severe Late Complications in Chemoradiotherapy-treated Head and Neck Cancer Patients | Chapter 3 | New Horizons in Medicine and Medical Research Vol. 12

In head and neck squamous cell carcinomas, radiation, in particular concurrent chemoradiotherapy (C-CRT), considerably increases disease control and survival rates (HNSCCs). These improvements are, however, typically followed with a rise in the frequency of severe consequences that significantly reduce the patient's functioning and quality of life and are primarily brought on by the underlying chronic systemic inflammation. Evidence currently available suggests that identifying novel immunological and inflammatory biomarkers before medication may be helpful in predicting severe oral cavity issues that may occur after treatment. These biomarkers might be used to help identify high-risk patients and direct treatment and follow-up procedures for them. The goal of the current review is to highlight the information that is currently available as well as the most plausible mechanisms that connect chronic inflammation to the development of serious long-term C-CRT problems. with an emphasis on dental losses following therapy, which might help identify high-risk individuals and prompt the implementation of preventative or therapeutic measures for them.

Author(s) Details:

Busra Yilmaz,

Department of Oral and Maxillofacial Radiology, Faculty of Dentistry, Baskent University, Ankara, Turkey.

Efsun Somay,

Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Baskent University, Ankara, Turkey.

Ahmet Kucuk,

Department of Radiation Oncology, Mersin City Hospital, Mersin, Turkey.

Berrin Pehlivan,

Department of Radiation Oncology, Bahcesehir University, Istanbul, Turkey.

Ugur Selek,

Department of Radiation Oncology, School of Medicine, Koc University, Istanbul, Turkey and Department of Radiation Oncology, MD Anderson Cancer Center, The University of Texas, Houston, TX, USA.

Erkan Topkan,

Department of Radiation Oncology, Faculty of Medicine, Baskent University, Adana, Turkey.

Please see the link here: https://stm.bookpi.org/NHMMR-V12/article/view/7269