This study's goal is to assess the impact of long-term usage of combination oral contraceptives (COC; ethinyl estradiol and levonorgestrel) on metabolic syndrome indicators in adult female wistar rats, as well as any potential therapeutic treatment.
64 female Wistar rats were given either distilled water, Norethindrone, COC,
Intranasal Insulin, Saxagliptin, Metformin, or INI+MET or INI+SAX in this
study. After 8 weeks of COC exposure, the mice were separated into therapeutic
groups. Indicators such as changes in body weight, insulin levels, inflammatory
cytokines, glycated haemoglobin (Hb1Ac), and fasting blood glucose (FBG) levels
were assessed. Treatment with INI+SAX and INI+MET considerably decreased FBG
and Hb1Ac levels, while also significantly raising insulin levels in the
INI+MET groups (p (leq) 0.05). Analysis of the serum lipid profile showed a
statistically significant decrease in HDL levels, which were significantly
increased in the INI+SAX group. In the INI+MET group, the decreased catalase
activity shown in the COC group was reversed (p (leq) 0.05). The effects of COC
therapy on the level of TNF-(alpha) were not significantly increased, while the
effects of INI and INI + MET were. It has been proven that using MET, SAX, and
INI together can reverse a number of MetS indices. This project will include a
clinical phase to support and validate the preclinical findings.
Author(s) Details:
Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin,
Nigeria.
Joy Folahan,
Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin,
Nigeria.
Olalekan Agede,
Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin,
Nigeria.
Olufunke Olorundare,
Department of Pharmacology and Therapeutics, University of Ilorin, Ilorin,
Nigeria.
Please see the link here: https://stm.bookpi.org/NHMMR-V12/article/view/7279
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