A Novel Bioscaffold Material-based Transplantable Liver Reconstruction | Chapter 12 | New Horizons in Medicine and Medical Research Vol. 12

The interest in tissue engineering with a decellularization/recellularization technique is now promising for liver regeneration as end-stage liver disease (ESLD) is a significant cause of mortality globally. The normal whole liver-derived decellularized scaffold (nDLS) maintains the liver's natural symphonic structure and bioactive molecules, and it has the ability to form a de novo liver that is suitable for transplantation following recellularization. A unique strategy must be developed since the nDLS's inactive ECM negatively affects seed cell survival and hemocompatibility, which are major obstacles to effective liver rebuilding. This chapter offers a thorough analysis of how these shortcomings might be transformed into the industry's present issues and suggests a few possibly workable solutions. concentrating mostly on a unique liver engineering approach based on decellularized liver scaffolds (rDLS). We hypothesise that the fundamental ideas required for the rDLS's benefits over the nDLS in liver reconstruction procedures. The criteria for significant barriers to utilising rDLS are also explored in depth.

Author(s) Details:

Deyu Hu,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China and Bioengineering College, Chongqing University, No. 175 Gaotan, Shaping Ba Distract, Chongqing 400044, China.

Zhenyu Wu,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China.

Jiejuan Lai,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China.

Min Yan,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China and Department of Nuclear Medicine, the First Hospital of Shanxi Medical University, Taiyuan, 030000, China.

Quanyu Chen,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China.

Leida Zhang,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China.

Hongyu Zhang,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China.

Lianhua Bai,

Hepatobiliary Institute, Southwest Hospital, Army Medical University, No. 30 GaotanYan, Shaping Ba District, Chongqing 400038 China and  Bioengineering College, Chongqing University, No. 175 Gaotan, Shaping Ba Distract, Chongqing 400044, China and Department of Nuclear Medicine, the First Hospital of Shanxi Medical University, Taiyuan, 030000, China.

Please see the link here: https://stm.bookpi.org/NHMMR-V12/article/view/7281