Association of Epstein - Barr virus with Oral Squamous Cell Carcinoma and Oral Potentially Malignant Disorders | Chapter 10 | Emerging Trends in Disease and Health Research Vol. 8

The cause of oral squamous cell carcinoma (OSCC) varies. Two etiological factors that may interfere with the physiological mechanisms that regulate cellular proliferation include a genetic predisposition or the presence of oncogenic viruses. The purpose of the study was to ascertain if the Epstein-Barr virus (EBV) is associated with oral squamous cell carcinoma and other potentially cancerous conditions (OPMD). The study's goal was to determine the amount of EBV in oral exfoliated cells from OSCC and OPMD patients. Oral exfoliated cells were taken from participants with OSCC (n = 19), OPMD (n = 23), and healthy people (n = 39) who had not been diagnosed with any harmful conditions. DNeasy Blood & Tissue Kits were used to extract the DNA (Qiagen, Germany). The QuantiNova® SYBR® Green PCR Kit was then used to perform quantitative real-time PCR (Qiagen, Germany). Very elevated EBV loads were found in the oral exfoliated cells of OSCC and OPMD patients compared to healthy persons. EBV is an oral resident, as evidenced by the presence of EBV DNA in all three categories of people. The high incidence of EBV DNA in OSCC and OPMD, in addition to its existence, demonstrates a connection between the two illnesses. There is a strong correlation between EBV and OSCC and OPMD, as indicated by the increased chances and risk ratio for EBV copy number. EBV DNA levels in OSCC and OPMD oral exfoliated epithelial cells may be measured for the first time in this investigation calls.

Author(s) Details:

S. Leena Sankari,

Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai- 600100, Tamil Nadu, India.

K. Mahalakshmi,

Department of Microbiology / Research Lab for Oral and Systemic Health, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai- 600100, Tamil Nadu, India.

G. M. Kailash Kumar,

Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai- 600100, Tamil Nadu, India.

K. M. K. Masthan,

Department of Oral Pathology and Microbiology, Sree Balaji Dental College and Hospital, Bharath Institute of Higher Education and Research, Chennai- 600100, Tamil Nadu, India.

V. Naveen Kumar,

Immu Genix Biosciences Pvt Ltd, Perambur, Chennai-600011, Tamil Nadu, India.

Please see the link here: https://stm.bookpi.org/ETDHR-V8/article/view/7236