Contrast-induced nephropathy is the most frequent side effect of both coronary angiography (CAG) and percutaneous coronary intervention (PCI) (CIN). The current study's objective is to determine if serum cystatin C can be utilised to diagnose CIN 24 hours following elective CAG and/or PCI in individuals.
The research included 80 participants with elective cardiology (48 males, 32
females). The study was conducted in Holy Karbala, Iraq, in the heart
catheterization lab of the Al-Hussein Medical City/ Karbala Health Directorate.
Blood urea, estimated GFR, serum cystatin C, and serum creatinine are among the
laboratory and clinical tests that are performed.
19 patients (23.8 percent) with renal impairment ranging from grade 0 to 2 had
contrast-induced nephropathy. Serum creatinine, cystatin C, and eGFR all rose
considerably (p0.001, 0.01 correspondingly) after angiography/angioplasty
operations for 24 hours. Creatinine had a greater area under the curve
(p=0.001), 78.9% sensitivity, and 60.7 percent specificity than serum cystatin
C (95 percent CI=0.673-0.881), according to a receiver-operating characteristic
analysis. P=0.001, sensitivity=78.9%, specificity=64%, and a cystatin C
threshold level of >7 ng/ml. A reliable biomarker for early detection of
contrast-induced nephropathy was cystatin C.
Author(s) Details:
Department of Biochemistry, College of Medicine, University of Kerbala/
Holy Karbala, Iraq.
M. H. Dheyauldeen,
Department of Biochemistry, College of Medicine, University of Kerbala/
Holy Karbala, Iraq.
M. A. Al-Mukhtar,
Center of Radiology, Holy Karbala, Iraq.
S. Y. Al-Jawad,
Center of Cardiology, Holy Karbala, Iraq.
R. M. Al-Saegh,
Department of Nephrology, College of Medicine, University of Kerbala/ Holy
Karbala, Iraq.
Please see the link here: https://stm.bookpi.org/NHMMR-V12/article/view/7272
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