This study's goal is to assess how well platelet rich plasma and autologous conditioned serum work to relieve pain, stiffness, and improve function in patients with early osteoarthrosis of the knee. The diarthrodial joint's synovial lining fails in osteoarthrosis. The most typical cause of persistent disability in elderly people is knee osteoarthrosis. The prevalence of osteoarthrosis is rising in India due to the population's longer average lifespan. Platelet rich plasma is a volume of plasma with a greater platelet content than peripheral blood (Prp). Prp's effectiveness in treating musculoskeletal conditions, such as osteoarthrosis, has been demonstrated in a number of basic, preclinical, and even clinical case studies and trials. An autologous blood product called autologous conditioned serum (Acs) contains more interleukin-1 receptor antagonist (il-1ra), a naturally occurring interleukin-1 inhibitor (il-1). An intriguing new treatment option for knee osteoarthrosis has been identified through our study on acs and platelet-rich plasma, and it has demonstrated effectiveness during a two-year monitoring period.
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