The goal of this study was to create a non-pressurized topical spray formulation to improve diclofenac diethylamine penetration by obstructing the lipoidal membrane. A prototype formulation and thirty other formulations were created (using various concentrations of permeation enhancer, cooling, buffering, film forming agent, plasticizer, and lecithin), and their characterization and optimization were carried out (FTIR spectroscopy, drug release, skin irritation, and kinetics study using the Higuchi/Korsmeyer Peppa's plot). As a dispensing system, a screw neck HDPE bottle with metered spray (200 mcl) pump and actuator was chosen. The spray pump is powered by the mechanical energy produced by the actuator's depression. The improved formulation (F30) was found to have a drug release of 93.3 percent 3.1 gcm-2, and an in-vitro research exhibited significant plus immediate topical drug penetration. F30 displayed super case (II) transport, erosion release mechanism, and no skin-irritation score, according to the ton>value. The study's goal is to lower the expense of the formulation while also making it more environmentally friendly.
Author(S) Details
Neelam Pawar
Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana, 127021, India.
View Book:- https://stm.bookpi.org/CAPRD-V3/article/view/4444
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