A Systematic Review on Modulation of Oral Biofilm and Immune Response Associated to Mucosa with Probiotic Bacteria as a Potential Approach in the Prevention of Dental Caries | Chapter 4 | Issues and Development in Health Research Vol. 4

 Background: For the control of dental caries, a disorder with a high incidence and prevalence worldwide, a range of methods have been devised. The use of probiotic strains for the modification of dental biofilm in the prevention of caries has been researched, but the available information suggests that different methodology are used in different studies, and the strains tested differ from one study to the next. The goal of this study was to see how effective probiotic strains are at preventing caries by modulating biofilm and the immune response associated with the oral mucosa. Methods: From 2010 to 2020, a search was conducted in the scientific databases PubMed, Cochrane, and Science Direct, prioritising randomised double and triple-blind clinical trials, with a total of 20 studies to be assessed. The selection criteria followed the guideline for Preferred Reporting Items for Systematic Reviews. Results: Various varieties of probiotic bacteria were examined in the research, with Lactobacillus paracasei prevailing. While the majority of clinical trials demonstrate a positive response in terms of a considerable reduction in Streptococcus mutans in the oral microbiota, only a few research have looked at salivary pH and sIgA levels. Conclusions: Due to the variability of the research reviewed and the complex character of dental caries, we cannot say that probiotic therapy is 100% beneficial in preventing this disease. Although probiotic therapy can aid in the prevention of caries by managing the microbial component, there are other factors that can contribute to the development of caries.

Author(s) Details

Prof. María de Lourdes Rodríguez Coyago
Stomatology Clinic and Microbiology, School of Dentistry, University of Cuenca-Ecuador, Ecuador.
Researcher at the Institute for Research in Microbiology and Parasitology (IMPaM), University of Buenos Aires, Argentina.

Juan Fernando Buestan Zambrano
School of Dentistry, University of Cuenca-Ecuador, Ecuador.

Jessica Micaela Yamunaqué Vire
School of Dentistry, University of Cuenca-Ecuador, Ecuador.

María Paz Pinos Gavilanes
School of Dentistry, University of Cuenca-Ecuador, Ecuador.

Lesly Damaris Osorio Ayala
School of Dentistry, University of Cuenca-Ecuador, Ecuador.


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