Data Mining and Evaluation of Single Arm Clinical Studies | Chapter 2 | Recent Developments in Engineering Research Vol. 3

 

Lifetime analyses frequently apply a parametric functional description from measured data of the
Kaplan-Meier non-parametric estimate (KM) of the survival probability. The cumulative Weibull
distribution function (WF) is the primary choice to parametrize the KM. but some others (e.g.
Gompertz, logistic functions) are also widely applied. We show that the cumulative two-parametric
Weibull function meets all requirements. The Weibull function is the consequence of the general selforganizing behavior of the survival, and consequently shows self-similar death-rate as a function of the time. The ontogenic universality as well as the universality of tumor-growth fits to WF. WF
parametrization needs two independent parameters, which could be obtained from the median and
mean values of KM estimate, which makes an easy parametric approximation of the KM plot. The
entropy of the distribution and the other entropy descriptions are supporting the parametrization
validity well. The goal is to find the most appropriate mining of the inherent information in KM-plots.
We show clinical examples of oncological hyperthermia treatment, evaluated by single-arm study. The
method which we chosen is the modulated electrohyperthermia (mEHT, oncothermia ®) which is
applied in the final stages of the cancer, and no conventional treatment as control is available in many
studies. We show the two-parameter WF fits to the non-parametric KM survival curve in a real study
of 1180 cancer patients offering satisfactory description of the clinical results. Two of the 3
characteristic parameters of the KM plot (namely the points of median, mean or inflection) are enough
to reconstruct the parametric fit, which gives support of the comparison of survival curves of different
patient’s groups. Objective in this chapter is to find a parametric description of overall survival, which fits the selforganized processes and is able to show the inherent information of survival measurements of cancer patients in advanced cases, when the curative conventional and evidence-based proven therapies fail.

Author (s) Details

Dr. O. Szasz
Biotechnics Department, Faculty of Mechanical Engineering, St. Istvan University, Hungary.

A. M. Szasz
Division of Oncology, Department of Internal Medicine and Oncology, Semmelweis University, Budapest, Hungary

Dr. G. P. Szigeti
Innovation Center, Semmelweis University, Budapest, Hungary

Prof. Dr. A. Szasz
Biotechnics Department, Faculty of Mechanical Engineering, St. Istvan University, Hungary.

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