Typhoid fever is a systemic infection,
caused mainly by Salmonella typhi found only in man. In 2010
there were 27 million cases reported,
while in 2003 it resulted in about 161,000 deaths. The risk of
death may be as high as 25% without
treatment, while with treatment it is between 1% and 4%.
Typhoid fever is treated with antibiotics
which kill the bacterium. Comparative analysis of antimicrobial
potency of six common fluoroquinolone
antibiotics was done. They were chosen based on their
availability and affordability which
includes: Ciprofloxacin, Pefloxacin, Levofloxacin, Norfloxacin,
Ofloxacin and Sparfloxacin, in the
treatment of Salmonela typhi infections. Sensitivity test of different
concentrations of the six
fluoroquinolones were carried out on the test organism (Salmonella tyhpi)
using agar well diffusion method. The
Minimum Inhibitory Concentration (MIC) which indicates the
strength of each of the fluoroquinolones
used on the test organism were determined. The
fluoroquinolones attain excellent tissue
penetration, kill S. typhi in its intracellular stationary stage in
monocytes/macrophages and achieve higher
active drug levels in the gall bladder than other drugs.
The result obtained showed that
Pefloxacin had the highest antibacterial strength against the test
organism with MIC of 0.0003, followed by
Norfloxacin (0.0006), Ciprofloxacin (0.0010), Levofloxacin
(0.0016), Ofloxacin (0.0042) and
Sparfloxacin having the lowest with MIC of 0.0398. The analysis of
variance (ANOVA) showed a significant
difference (P<0.05) among the MIC of the six
fluoroquinolones used. Post Hoc Test
result indicates a significant of 1.000 among the MIC of the six
fluoroquinolones.
Author (s)
Details
Akeem Agboke
Department of Pharmaceutics and
Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo,
Nigeria.
Ekanem Etim
Department of Pharmaceutics and
Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Nigeria.
View Book :- https://bp.bookpi.org/index.php/bpi/catalog/book/248
No comments:
Post a Comment