Diabetes is a serious chronic condition caused by either
insufficient insulin production or the body's inability to effectively use the
insulin it produces, leading to a persistent metabolic imbalance. Increased
serum glucose can cause altered insulin signalling, and dyslipidaemia leads to
several pathological alterations in neurons, glia, and vascular cells, leading
to nerve dysfunction and, ultimately, neuropathy, including DNA damage and
endoplasmic reticulum stress. The low-density lipoprotein receptor–related
protein 1 (LRP-1) is a type I transmembrane protein belonging to the
low-density lipoprotein receptor (LDL-R) family. C/EBP homologous protein
(CHOP) is a major transcription factor in endoplasmic reticulum
(ER)stress-mediated apoptosis and has widely documented roles in the
pathogenesis of type 2 diabetes mellitus (T2DM) and diabetic complications. In
this review, we are trying to determine the role of LRP1 and CHOP genes in
modulating ER stress and their role in the pathophysiology of diabetes. We
conducted a review using the Medline, Scopus, and Cochrane databases to examine
the literature regarding the distinctions in neuropathy between type 1 and type
2 diabetes, variations in neuropathies, molecular biomarkers associated with
the LRP1 gene, and CHOP expressions, along with their impact on diabetic
neuropathies and related complications. This review can help establish novel
therapeutic strategies for preventing and managing ER stress and diabetes.
Author(s) Details
Neha Saboo
Department of Physiology, RUHS College of Medical Sciences, Jaipur, Raj,
India.
Sudhanshu Kacker
Department of Physiology, RUHS College of Medical Sciences, Pratap Nagar,
Jaipur, Raj, India.
Gaurav Dalela
Department of Microbiology, RUHS College of Medical Sciences, Jaipur, Raj,
India.
Ila Joshi
RUHS College of Medical Sciences, Jaipur, India.
Ambrin Zenab
Department of Physiology, RUHS-CMS, India.
Please see the book here:- https://doi.org/10.9734/bpi/msraa/v10/6139
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