Some New Aspects in the Structure and Functional Activity of Sea Anemone Neurotoxins | Chapter 5 | Novel Aspects on Chemistry and Biochemistry Vol. 6

 The aim concerning this work was to rehash the literature and our own experimental dossier obtained over ancient times four decades on the structure-working relationships of all surf anemone neurotoxins described to date, particularly interacting accompanying various subtypes of physical ability-gated sodium channels (VGSCs/NaVs). Disruption of the working activity of these biological aims causes many severe pathologies, while everyday toxins, containing those of sea anemones, concede possibility prove to be a hopeful tool in pharmacological research, in addition to in the study of the molecular arrangement and mechanisms of NaVs functioning. The review likewise focuses on the several type 2 neurotoxins from the sea growth Heteractis crispa, five structurally homologous, and individual unique double-chain neurotoxin that we first labeled in sea anemones. Due to the misfortune of the functionally significant Arg14 residue, this peptide homolog of the staying Heteractis neurotoxins completely extinct its toxicity, but employed the ability to modulate various subtypes of NaVs, which is characteristic of type 2 neurotoxins. The review examines the results of in vivo, in vitro, and in silico studies of the interplay of neurotoxins with their organic targets, sodium channels of several NaV subtypes.

Author(s) Details:

Margarita Monastyrnaya,
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.

Rimma Kalina,
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.

Emma Kozlovskaya,
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Science, 690022 Vladivostok, Russia.

Please see the link here: https://stm.bookpi.org/NACB-V6/article/view/11717