Applications of Activated Methylene Isocyanides in the Synthesis of Azoles| Chapter 7 | Recent Progress in Chemical Science Research Vol. 6

 Synthesis of thiazoles apiece base induced cyclization of alive methylene isocyanides with dithioesters, xanthate esters, α-oxodithioesters and 2-oxo-2-(amino) ethanedithioates are presented in this place chapter. Besides, a crew approach for the synthesis of oxazoles is developed for one oxidation of alcohols and arylmethyl bromides trailed by cyclization with activated methylene isocyanides is still illustrated. In the same way, combination of oxazoles by the reaction of tosyl chloride accompanying carboxylic acids followed by cyclization accompanying tosylmethyl isocyanide (TosMIC) in the presence of a base is described. Finally, combination of imidazoles by the cyclization of TosMIC and ethyl isocyanoacetate accompanying N(N), N'-di(tri)substituted carbamimidothioates is also presented. The credible mechanisms for the establishment of azoles (thiazoles, oxazoles and imidazoles) are also given in this place chapter.

Author(s) Details:

Toreshettahally R. Swaroop,
Department of Studies in Organic Chemistry, University of Mysore, Manasagangotri, Mysuru - 570 006, Karnataka, India.

Maralinganadoddi P. Sadashiva,
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysuru - 570 006, Karnataka, India.

Kanchugarakoppal S. Rangappa,
Institution of Excellence, University of Mysore, Manasagangotri, Mysuru - 570 006, Karnataka, India.

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