The effect of pregnant rat bone marrow cells (rBMC) or human umbilical blood cord cells (hUBCC) transplantation on the growth of rat foetuses during pregnancy is being investigated. rBMC or hUBCC were transplanted intravenously or subdermally once each during SD 7, 8, 9, 10, 11, 12 or 13. SD18 was assigned to the general appearance and weight of the foetuses. The weight of foetuses grew to 835 15 mg after rBMC transplantation at SD 7-9; however, the weight of foetuses reduced to 587 5 mg after rBMC transplantation at SD 11-12. The foetuses weighed 848 8 mg after hBCC transplantation at SD 9-10. On SD 11 and 13 transplanting, it was reduced to 826 28 and 782 22 mg, respectively. It was shown that implanting cells with stem cell characteristics into pregnant rats during gastrulation increased the weight of the foetuses at SD's 18. Antirat, antirenal rabbit antisera were injected intravenously at the same time (AnRAnRR antisera). AnRAnRR antisera administered once during SDs 7-10 resulted in rat embryos with abnormalities at SDs 18. At SD's 11th and subsequent days of pregnancy, the teratogenic impact of AnRAnRR antisera was no longer present. The findings reveal that in vivo growth regulation and retardation of foetuses can be achieved through the transplantation of cells with stem cell capabilities or antirenal antisera injections, respectively.
Author(S) Details
V. M. Mikhailov
Institute of Cytology Russian Academy of Science, Russian Federation.
A. V. Sokolova
Institute of Cytology Russian Academy of Science, Russian Federation.
D. A. Ivolgin
Mechnikov Medical Academy, Russian Federation and Pokrovski Bank of Stem Cells, Saint Petersburg, Russian Federation.
V. M. Mikhailova
Institute of Cytology Russian Academy of Science, Russian Federation.
View Book:- https://stm.bookpi.org/RDMMR-V15/article/view/5017
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