Intradialytic Cardiovascular Exercise Training Alters Redox Status, Reduces Inflammation and Improves Physical Performance in End Stage Renal Disease Patients under Hemodialysis | Chapter 3 | Recent Developments in Medicine and Medical Research Vol. 13

 Introduction: Chronic kidney disease (CKD) is characterised by redox status (RS) disturbances and inflammation, which are significantly aggravated in end-stage renal disease (ESRD) (ESRD).

The goal of this study was to see how effective a 6-month intradialytic exercise training programme was at reducing RS, inflammation, and physical performance in ESRD patients.

Materials and Procedures: For six months, twenty hemodialysis (HD) patients (17 males, 3 females) were randomly allocated to either an intradialytic training (bedside cycling) group (TR; n = 10) or a control group (CON; n = 10) for intradialytic training (bedside cycling). Physical performance (VO2peak), functional capacity [North Staffordshire Royal Infirmary (NSRI) walk test, sit-to-stand test (STS-60)], quality of life [(short form-36 (SF-36)], RS [thiobarbituric acid reactive substances (TBARS), protein carbonyls (PC), reduced (GSH) and oxidised (GSSG) glutathione, GSH/GSSG ratio, total antioxidant capacity (TAC), catalase activity (

Results: Only in TR (p 0.01) did peak oxygen consumption (VO2peak) increase by 15%. Only TR's performance improved by 4–13% in NSRI, STS-60, and SF-36 (p 0.01). Exercise training decreased TBARS by 28%, PC by 31%, and hs-CRP by 15%, while increasing GSH by 52%, GSH/GSSG ratio by 51%, TAC by 59 percent, and CAT by 15% (p 0.01).

Conclusion: Chronic intradialytic cardiovascular exercise modifies RS, decreases inflammation, and improves performance in patients with ESRD, according to these data. Future research will need to look into this circumstance with a larger sample size in order to draw safe conclusions.

Author(S) Details

Apostolos Sovatzidis
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Athanasios Chatzinikolaou
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.

Ioannis G. Fatouros
School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece.

Stylianos Panagoutsos
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Dimitrios Draganidis
School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece.

Eirini Nikolaidou
Department of Plastic, Reconstructive and Hand Surgery & Burns ICU, General Hospital of Thessaloniki “G. Papanikolaou”, 57010 Thessaloniki, Greece.

Alexandra Avloniti
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.

Yiannis Michailidis
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.

Ioannis Mantzouridis
School of Physical Education and Sport Sciences, Democritus University of Thrace, 69100 Komotini, Greece.

Alexios Batrakoulis
School of Physical Education and Sport Sciences, University of Thessaly, Karies, 42100 Trikala, Greece.

Ploumis Pasadakis
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

Vassilis Vargemezis
Department of Nephrology, Faculty of Medicine, University Hospital of Alexandroupolis, Democritus University of Thrace, 68100 Alexandroupolis, Greece.

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